DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stim and Stim2

DIOPT Version :9

Sequence 1:	NP_523357.2	Gene:	Stim / 32556	FlyBaseID:	FBgn0045073	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	XP_038947488.1	Gene:	Stim2 / 117087	RGDID:	1304641	Length:	817	Species:	Rattus norvegicus

Alignment Length:	475	Identity:	188/475 - (39%)
Similarity:	278/475 - (58%)	Gaps:	44/475 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 SMGSGSADGACAADDFD------CYSGS-----VQDRFGMEAIASLHRQLDDDDNGNIDLSESDD 169
            |.|:.::..|.||.:..      |.|.|     .:|||.:||:.::|:|:|||.:|.|::.|||:
  Rat    96 SAGAAASPSAAAAGERQALLTDPCMSLSPPCFTEEDRFSLEALQTIHKQMDDDKDGGIEVDESDE 160

  Fly   170 FLREELKYDSGYEKRQKAFHFN-DDMHISVKELWEAWLRSEVHNWTIEQTTDWLAQSVQLPQYVD 233
            |:||::||.....|..   |.: :|.||:|::||:.|..|||||||:|.|..||.:.|:||||..
  Rat   161 FIREDMKYKDATNKHS---HLHREDKHITVEDLWKQWKTSEVHNWTLEDTLQWLIEFVELPQYEK 222

  Fly   234 LFKLHKVTGAALPRLAVNNLQYVGNVLGIKDPIHKQKISLKAMDVVLFGPPRETGTRW-KDYILV 297
            .|:.:.|.|..|||:||:...::.:.|.|.|..|:||:.|||:|||||||.......| ||:||.
  Rat   223 NFRDNNVKGTTLPRIAVHETSFMISQLKISDRSHRQKLQLKALDVVLFGPLTRPPHNWMKDFILT 287

  Fly   298 TLLLSAIIGCWYAYQQNKNAKRHLRRMAQDMEGLQRAEQSLQEMQKELERARMEQENVATEKLDL 362
            ..::..:.|||:||.|||.:|.|:.:|.:|:|.||.|||||.::|:.||:|:.|...||.||.:|
  Rat   288 ISIVIGVGGCWFAYTQNKTSKEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRTVAVEKQNL 352

  Fly   363 ERRL--------KEAPTLSSSNSDLEV-----QQLKKEIEMLRNELSRA--EFELVDNCWSPPPQ 412
            ||::        :||..|.......|.     |..::|:|.:|..|.:|  |||| .:.||.|..
  Rat   353 ERKMMDEINYAKEEACRLRELREGAECELSRRQYAEQELEQVRMALKKAEKEFEL-RSSWSVPDA 416

  Fly   413 LQSWLQYTYELESKNHQKKRTSAEKQLQSARE--------ACEKLRKKRSSLVGAFVSTHGKSID 469
            ||.|||.|:|:|.:.:..||.:||.||..|::        ..||::||||::.|.....|..|:|
  Rat   417 LQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEVAASYLMQAEKIKKKRSTVFGTLHVAHSSSLD 481

  Fly   470 DVDRSIVEARNALGDVTNELQERLHRWKQIETCLGLNIVNNNGLPYLENVLYGRNGGLQSSMGMS 534
            :||..|:||:.||.::|..|:|||.||:|||...|..|.:|:|||.|.:.||..:    |.:.|.
  Rat   482 EVDHKILEAKKALSELTTCLRERLFRWQQIEKICGFQIAHNSGLPSLTSSLYSDH----SWVVMP 542

  Fly   535 STKGSRARITNSTEDLDDES 554
            ........|....:|||:::
  Rat   543 RVSIPPYPIAGGVDDLDEDT 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stim	NP_523357.2	SAM_STIM-1,2-like	209..282	CDD:188903	36/72 (50%)
		SAM	210..271	CDD:197735	27/60 (45%)
		GBP_C	<312..392	CDD:303769	34/92 (37%)
		coiled coil	360..372	CDD:293879	5/19 (26%)
		coiled coil	381..392	CDD:293879	3/15 (20%)
		SOAR	410..507	CDD:293141	44/104 (42%)
Stim2	XP_038947488.1	SAM_STIM2	198..271	CDD:188973	36/72 (50%)
		Smc	<304..>513	CDD:224117	84/209 (40%)
		SOAR	414..519	CDD:406837	44/104 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354139
Domainoid	1	1.000	104	1.000	Domainoid score	I6560
eggNOG	1	0.900	-	-		E1_KOG4403
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	338	1.000	Inparanoid score	I2303
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185000at33208
OrthoFinder	1	1.000	-	-		FOG0001884
OrthoInspector	1	1.000	-	-		otm46050
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15136
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1416
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.900