DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Stim and stim1b

DIOPT Version :9

Sequence 1:	NP_523357.2	Gene:	Stim / 32556	FlyBaseID:	FBgn0045073	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	XP_005161345.1	Gene:	stim1b / 100005700	ZFINID:	ZDB-GENE-060531-4	Length:	668	Species:	Danio rerio

Alignment Length:	465	Identity:	185/465 - (39%)
Similarity:	279/465 - (60%)	Gaps:	51/465 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 CAADDFDCYSGSVQDR---FGMEAIASLHRQLDDDDNGNIDLSESDDFLREELKYDSGYEKRQKA 187
            |..|:..|     ||.   ...|||.|:|:.:|||.:|::|::|:|.||||:|||... :.:..:
Zfish    43 CGIDEILC-----QDENALLSFEAIRSIHKDMDDDADGSVDVTETDGFLREDLKYHDP-KGKHNS 101

  Fly   188 FHFNDDMHISVKELWEAWLRSEVHNWTIEQTTDWLAQSVQLPQYVDLFKLHKVTGAALPRLAVNN 252
            || ..|:.|:|:::|.:|..|||:|||:|:..:||...|:||||||.|:.:.::|..||||||.|
Zfish   102 FH-RADLLITVEDMWNSWKASEVYNWTVEEAEEWLTSFVELPQYVDSFRKNVISGKDLPRLAVKN 165

  Fly   253 LQYVGNVLGIKDPIHKQKISLKAMDVVLFGPPRETGTRWKDYILVTLLLSAIIGCWYAYQQNKNA 317
            ...:.:||.|.|..|.||:.|||:|.||||||....:..||.:||..::..:.|||:||.||:|.
Zfish   166 ATLLVSVLKIPDRSHAQKLQLKALDTVLFGPPVSRHSHLKDLMLVVSIIIGVGGCWFAYIQNRNY 230

  Fly   318 KRHLRRMAQDMEGLQRAEQSLQEMQKELERARMEQENVATEKLDLERRLKEAPTLSSSNSDLEVQ 382
            :.|:.:|.:|::|||||||||.:||::|:.|:.|...|..||::|||.::.           |::
Zfish   231 RDHMGKMIKDLDGLQRAEQSLLDMQQKLQIAQEEHHTVEEEKVNLEREMRS-----------EIE 284

  Fly   383 QLKKEIEMLR-------NELSR-----------------AEFEL-VDNCWSPPPQLQSWLQYTYE 422
            ..|:|.:.||       |||||                 ||.|| :.:.||||..||.|||.|:|
Zfish   285 AAKEEAQRLRELREGTENELSRRKYAEQELDQVRMALKKAERELELRSGWSPPDALQKWLQLTHE 349

  Fly   423 LESKNHQKKRTSAEKQLQSAREACEKLRKKRSSLVGAFVSTHGKSIDDVDRSIVEARNALGDVTN 487
            :|.:.:..|:.|||:||..|:|..||::|||:|:.|.|...|..|:||||..|:.|:.|||:||.
Zfish   350 VEVQYYNIKKQSAERQLIVAKEGAEKIKKKRASIFGTFHVAHSSSLDDVDHKILSAKKALGEVTA 414

  Fly   488 ELQERLHRWKQIETCLGLNIVNNNGLPYLENVLYGRNGGLQSSMGMSSTKGSRARITNSTEDLDD 552
            .|:|:||||:|||:....|||||.|:..|...|    ....:.:|:..:......:::..:|:|:
Zfish   415 ALREKLHRWQQIESLTNFNIVNNPGMSSLAAAL----NVDPAFLGIRPSTPQHLLLSDDLDDMDE 475

  Fly   553 ESIQ-GKLNF 561
            :.:. |.|.:
Zfish   476 DILSPGTLQY 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stim	NP_523357.2	SAM_STIM-1,2-like	209..282	CDD:188903	37/72 (51%)
		SAM	210..271	CDD:197735	29/60 (48%)
		GBP_C	<312..392	CDD:303769	29/79 (37%)
		coiled coil	360..372	CDD:293879	3/11 (27%)
		coiled coil	381..392	CDD:293879	2/10 (20%)
		SOAR	410..507	CDD:293141	47/96 (49%)
stim1b	XP_005161345.1	SAM_superfamily	122..195	CDD:301707	37/72 (51%)
		SAM	123..187	CDD:197735	30/63 (48%)
		NUDE_C	250..>332	CDD:282704	27/92 (29%)
		SOAR	337..434	CDD:293141	47/96 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596382
Domainoid	1	1.000	113	1.000	Domainoid score	I6085
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	334	1.000	Inparanoid score	I2395
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185000at33208
OrthoFinder	1	1.000	-	-		FOG0001884
OrthoInspector	1	1.000	-	-		otm24211
orthoMCL	1	0.900	-	-		OOG6_106940
Panther	1	1.100	-	-	O	PTHR15136
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1416
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.900