DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lcch3 and glrba

DIOPT Version :9

Sequence 1:	NP_996469.1	Gene:	Lcch3 / 32554	FlyBaseID:	FBgn0010240	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_571856.1	Gene:	glrba / 83412	ZFINID:	ZDB-GENE-010410-2	Length:	498	Species:	Danio rerio

Alignment Length:	489	Identity:	162/489 - (33%)
Similarity:	254/489 - (51%)	Gaps:	77/489 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 NVTQTISN-ILQGYDIRLRPNFGGEPLHVGMDLTIASFDAISEVNMDYTITMYLNQYWRDERLAF 102
            |.|..|.| :|..||.|:||||.|.|:...:::.|.||.:|.|..|||.:.::|.|.|.|.||..
Zfish    54 NSTSNILNRLLMTYDSRIRPNFKGIPVEDKVNIFINSFGSIQETTMDYRVNIFLRQRWNDPRLRL 118

  Fly   103 NIFGQYFDDENDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKLVRLGGDGAVTYG 167
                      ..|..||.||:.....:.:|.||.||||:||:..||||:.|.|:.:..:|.|...
Zfish   119 ----------PTDFKSDALTVDPKMFQCLWKPDLFFANEKNANFHDVTQENILLFIFRNGDVLIS 173

  Fly   168 MRFTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYWKP-TPVRGVEDAELPQFTI----I 227
            ||.:.||:|.:.|..:|:|:|.|.:::||:|||..|:|..|:. .||: :::..||||.:    |
Zfish   174 MRLSVTLSCPLALQLFPMDTQYCKMQLESFGYTTKDLVFMWQSGDPVQ-MDEIALPQFDVKQEDI 237

  Fly   228 GYETNDRKERLATGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHEATSARVALG 292
            .| .|..|....||.|..:.:.|.|:|.:|:::...|.|::|||:|||:|||||.:|::|||.||
Zfish   238 KY-ANCTKFYPGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLG 301

  Fly   293 ITTVLTMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVNYTYWGKRAKKKI--KK 355
            |.:||::::..|.:.|.||::||||||||:::.|.::.||:|:|||.|....   .:.|:|  :|
Zfish   302 ILSVLSLSSECTSLASELPKVSYVKAIDIWMIACLLYGFASLVEYAVVQVML---NSPKRIEAEK 363

  Fly   356 VKECCPGKIGKSERSETCST--------------TEDIIELQDVRMSPIPS-LRRGTYNATLDSI 405
            :|.....|..:.|......|              |..::|.:..::....| ||...::.
Zfish   364 IKMAEKEKAREKENKTPAKTNSANGTGGTPIHVSTLQVVENRCKKVCTSKSDLRSNDFSI----- 423

  Fly   406 GTETMNLGKFPPSFRITR--NYG--------TGHSQLRRRAQRGISTRPRMLHALKRGASAIKAT 460
                  :|..|..|.::.  .||        :|..| .:..::....:|.:..|.||
Zfish   424 ------VGSLPRDFELSNFDCYGKPIEVTDASGKPQ-NKNNKKPAPPKPVIPSAAKR-------- 473

  Fly   461 IPKIKDVNIIDKYSRMIFPISFLAFNLGYWLFYI 494
                     :|.|:|.:||.:||.||:.||..|:
Zfish   474 ---------VDLYARALFPFTFLFFNVIYWSVYL 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	161/486 (33%)
		Neur_chan_LBD	47..256	CDD:280998	80/213 (38%)
		Neur_chan_memb	263..490	CDD:280999	74/253 (29%)
glrba	NP_571856.1	LIC	52..497	CDD:273305	161/486 (33%)
		Neur_chan_LBD	59..265	CDD:280998	82/217 (38%)
		Neur_chan_memb	272..494	CDD:280999	74/253 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810