DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lcch3 and Gabrp

DIOPT Version :9

Sequence 1:	NP_996469.1	Gene:	Lcch3 / 32554	FlyBaseID:	FBgn0010240	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_112291.1	Gene:	Gabrp / 81658	RGDID:	620532	Length:	440	Species:	Rattus norvegicus

Alignment Length:	452	Identity:	177/452 - (39%)
Similarity:	255/452 - (56%)	Gaps:	59/452 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 NILQGYDIRLRPNFGGEPLHVGMDLTIASFDAISEVNMDYTITMYLNQYWRDERLAFNIFGQYFD 110
            |:..||:..|||||||:|:.:.:.|.|||..:|||.|||||.|:||.|.|.|.||.|
  Rat    43 NLTAGYNKFLRPNFGGDPVRIALTLDIASISSISESNMDYTATIYLRQRWTDPRLVF-------- 99

  Fly   111 DENDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKLVRLGGDGAVTYGMRFTTTLA 175
                :| :...||.....|.:|||||:....|.||||:||..|:|:||..:|.|.|.:|.|||:.
  Rat   100 ----EG-NKSFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVT 159

  Fly   176 CMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYW--KPTPVRGVEDAELPQFTIIGYETNDRKERL 238
            |.|||..||:|:|.|.:::||:||..:||...|  ....|||:|:..|.|:||..|.|.....:.
  Rat   160 CNMDLSKYPMDTQTCKLQLESWGYDGNDVEFSWLRGNDSVRGLENLRLAQYTIQQYFTLVTVSQQ 224

  Fly   239 ATGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHEATSARVALGITTVLTMTTIS 303
            .||.|.||.|.|:|:||:.||:.:||:||..:|:||||||||:.|:..||..:|:||||:|||:.
  Rat   225 ETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLESVPARTCIGVTTVLSMTTLM 289

  Fly   304 TGVRSSLPRIS-YVKAIDIYLVMCFVFVFAALLEYAAVNYTYWGKRAKKKIKKVKECCPGKIGKS 367
            .|.|:|||..: ::||||:||.:||.|||.||||||..:|:...:.|      ||:..|.|  .|
  Rat   290 IGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQMA------VKDRGPAK--DS 346

  Fly   368 ERSETCSTTEDIIELQDVRMSPIPSLRRGTYNATLDSIGTETMNLGKFPPSFRITRNYGTGHSQL 432
            |.          :.:.::..|.|.|.:|....|:::..|...              ||    |.|
  Rat   347 EE----------VNITNIINSSISSFKRKISFASIEISGDNV--------------NY----SDL 383

  Fly   433 RRRAQRGISTRPRMLHALKRGASAIKATIPKIKDVNIIDKYSRMIFPISFLAFNLGYWLFYI 494
            ..:|    |.:.:.:...|.|......|   |::.:.:|:||:::||:.|:..|:.||.:|:
  Rat   384 TMKA----SDKFKFVFREKIGRIIDYFT---IQNPSNVDRYSKLLFPLIFMLANVFYWAYYM 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	176/449 (39%)
		Neur_chan_LBD	47..256	CDD:280998	93/210 (44%)
		Neur_chan_memb	263..490	CDD:280999	77/227 (34%)
Gabrp	NP_112291.1	LIC	43..437	CDD:273305	176/449 (39%)
		LGIC_ECD	60..241	CDD:355788	83/193 (43%)
		Cys-loop	159..174	CDD:349787	8/14 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D226476at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920