Protein Alignment Lcch3 and gabra5

DIOPT Version :10

• Sequence 1: NP_996469.1
• Gene: Lcch3 / 32554
• FlyBaseID: FBgn0010240
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: XP_005166139.1
• Gene: gabra5 / 799124
• ZFINID: ZDB-GENE-081104-30
• Length: 453
• Species: Danio rerio
• Alignment Length: 506
• Identity: 159/506 - (31%)
• Similarity: 239/506 - (47%)
• Gaps: 102/506 - (20%)

  Fly    12 GLFFFLLGAQLQLIRCI----RKDVLAGRLENVTQTISNILQGYDIRLRPNFGGEPLHVGMDLTI 72
            |:.|..|...|.|.:..    ::..|...:...|:.:..:|.|||.||||..|.:...:..::.:
Zfish    17 GVLFMTLTCHLSLSQSTTGTPKESELNDNITVFTRILDGLLDGYDNRLRPGLGEKVTEIKTNIFV 81

  Fly    73 ASFDAISEVNMDYTITMYLNQYWRDERLAFNIFGQYFDDENDDGISDVLTLSGDFAEKIWVPDTF 137
            .||..:|:..|:|||.::..|.|:||||.|.            |..::|.|:...|..||.||||
Zfish    82 TSFGPVSDTEMEYTIDVFFRQSWKDERLCFK------------GPMEMLPLNNLLASNIWTPDTF 134

  Fly   138 FANDKNSFLHDVTERNKLVRLGGDGAVTYGMRFTTTLACMMDLHYYPLDSQNCTVEIESYGYTVS 202
            |.|.|.|..|::|..|||:||..||.:.|.||.|.:..|.|.|..:|:|:..|.::..||.|.:|
Zfish   135 FLNGKKSIAHNMTTPNKLLRLKDDGTLLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYAYPIS 199

  Fly   203 DVVMYWKPTPVRGV----EDAELPQFTIIGYETNDRKERLATGVYQRLSLSFKLQRNIGYFVFQT 263
            :||..|...|.:.|    |.:.|.|:.:||:.........:.|.|..:...|.|:|.|||||.||
Zfish   200 EVVYKWTKGPGKSVVVAEEGSRLNQYHLIGHTAGTEDISTSRGQYTVMMAHFYLKRKIGYFVIQT 264

  Fly   264 YLPSILIVMLSWVSFWINHEATSARVALGITTVLTMTTISTGVRSSLPRISYVKAIDIYLVMCFV 328
            |:|..:.|:||.||||:|.|:..||...|:||||||||:|...|:|||:::|..|:|.::.:|:.
Zfish   265 YMPCFMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYA 329

  Fly   329 FVFAALLEYAAVNY---TYWGKRAKKKI--KKVKECCPGKIGKSERSETCSTTED---------- 378
            |||:||:|:|.|||   ..|....||.:  ::.|:..|..:.|...:.|.:..:|
Zfish   330 FVFSALIEFATVNYFTKRSWAWDGKKALEAQQPKKKDPLALSKKPNNFTANINKDAAISTISNST 394

  Fly   379 IIELQDVRMSPIPSLRRGTYNATLDSIGTETMNLGKFPPSFRITRNYGTGHSQLRRRAQRGISTR 443
            .::|:.....|.|..:: |||:
Zfish   395 TVQLKSAEAKPAPDPKK-TYNS------------------------------------------- 415

  Fly   444 PRMLHALKRGASAIKATIPKIKDVNIIDKYSRMIFPISFLAFNLGYWLFYI 494
                                   |:.|||.||::||:.|..|||.||..|:
Zfish   416 -----------------------VSKIDKMSRIVFPVLFGTFNLVYWATYL 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	157/500 (31%)
gabra5	XP_005166139.1	LIC	19..442	CDD:455710	157/501 (31%)
		LGIC_ECD_GABAAR_A5	58..256	CDD:349839	73/209 (35%)
		Cys-loop	173..187	CDD:349839	5/13 (38%)