DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lcch3 and Gabre

DIOPT Version :9

Sequence 1:	NP_996469.1	Gene:	Lcch3 / 32554	FlyBaseID:	FBgn0010240	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_075579.1	Gene:	Gabre / 65191	RGDID:	68320	Length:	989	Species:	Rattus norvegicus

Alignment Length:	496	Identity:	142/496 - (28%)
Similarity:	233/496 - (46%)	Gaps:	100/496 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 GRLENVTQTISNILQGYDIRLRPNFGGEPLHVGMDLTIASFDAISEVNMDYTITMYLNQYWRDER 99
            |:|...:|.::.||..||.:|||:.|.:|..|.:.:.:.|...||.::|:|:|.:...|.|.|||
  Rat   550 GKLTRASQILNTILSNYDHKLRPSIGEKPTVVTVKVFVNSLGPISILDMEYSIDIIFYQTWYDER 614

  Fly   100 LAFNIFGQYFDDENDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKLVRLGGDGAV 164
            |.:|            ...:.|.|.|:...::|:|||||.|.|.:..:|:|..|::..:..||.|
  Rat   615 LRYN------------DTFETLILHGNVVSQLWIPDTFFRNSKRTQEYDITIPNQMALIHKDGKV 667

  Fly   165 TYGMRFTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYWKPTPVRGVEDA----ELPQFT 225
            .|.:|.|....|.:.:..:|:||.:|.:...|:.|...:::..|:...::  .||    :|.:|.
  Rat   668 LYTVRMTIDARCSLHMLNFPMDSHSCPLSFSSFSYDEHEMIYKWENFKLK--IDAKNTWKLLEFD 730

  Fly   226 IIGYETNDRKERLAT--GVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHEATSAR 288
            ..|  .|::.|.::|  |.:..::..|.:.|..|:.|||.|:||.:..|||||||||..||.:||
  Rat   731 FTG--VNNKTEIISTPVGDFMVMTFFFNVSRRFGFIVFQNYIPSSVTTMLSWVSFWIKIEAAAAR 793

  Fly   289 VALGITTVLTMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVNY-TY-------- 344
            .::|:::||||.|:.|..|.:.||:||:.|:|.|:.:|||..|..|||:..:|: ||
  Rat   794 ASVGVSSVLTMATLGTFSRKNFPRVSYLTALDFYIAICFVLCFCTLLEFTVLNFLTYNNIERQAS 858

  Fly   345 -------WGKRAKKKIK---KVKECCPGKIGKSERSETCS--TTEDIIELQDVRMSP------IP 391
                   ...||..:.:   :.:.....:..:.:....|.  |.|:..| :..:.||      .|
  Rat   859 PKFYQFPTNSRANARTRARARTRARARARARQQQEVFVCEIVTYEENAE-EGYQWSPRSRRPQCP 922

  Fly   392 SLRRGTYNATLDSIGTETMNLGKFPPSFRITRNY------GTGHSQLRRRAQRGISTRPRMLHAL 450
            ..|                 .|:....||:.|.|      ..|:|..|.|.         .:|..
  Rat   923 WRR-----------------CGRSYVCFRVLRKYFCMVPGCEGNSWQRGRI---------CIHVY 961

  Fly   451 KRGASAIKATIPKIKDVNIIDKYSRMIFPISFLAFNLGYWL 491
            :                  :|.|||::|||:|..||:.||:
  Rat   962 R------------------LDNYSRVLFPITFFFFNVVYWV 984

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	142/496 (29%)
		Neur_chan_LBD	47..256	CDD:280998	62/214 (29%)
		Neur_chan_memb	263..490	CDD:280999	71/259 (27%)
Gabre	NP_075579.1	Neur_chan_LBD	555..760	CDD:280998	62/220 (28%)
		LIC	557..983	CDD:273305	138/486 (28%)
		Neur_chan_memb	769..983	CDD:280999	71/258 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910