DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lcch3 and gabrz

DIOPT Version :9

Sequence 1:	NP_996469.1	Gene:	Lcch3 / 32554	FlyBaseID:	FBgn0010240	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001108214.2	Gene:	gabrz / 561738	ZFINID:	ZDB-GENE-080303-26	Length:	447	Species:	Danio rerio

Alignment Length:	502	Identity:	189/502 - (37%)
Similarity:	271/502 - (53%)	Gaps:	78/502 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 CGLFFFLLGAQLQLIRCIRKDVLAGRLENVTQTISNILQGYDIRLRPNFGGEPLHVGMDLTIASF 75
            |....|||  .|..|..|....:|...|.:..||..:::||:..|||.||..|:.|||.|.|||.
Zfish     4 CSFVGFLL--LLLFISRIMDGSVANTEEILPPTIQKLMKGYNKYLRPFFGNGPVTVGMSLDIASI 66

  Fly    76 DAISEVNMDYTITMYLNQYWRDERLAFNIFGQYFDDENDDGISDVLTLSGDFAEKIWVPDTFFAN 140
            |.|||:|||||.|::|.|.|.||||.|            || :..|:|.|...|.:||||||..:
Zfish    67 DTISEINMDYTATIFLRQRWTDERLCF------------DG-NKSLSLDGRLVELLWVPDTFIVD 118

  Fly   141 DKNSFLHDVTERNKLVRLGGDGAVTYGMRFTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVV 205
            .|.|||||:|..|:|:|:..:|.|.|.:|.|||:||.|||..||:|.|.|.:::||:||.|.|||
Zfish   119 SKKSFLHDITVENRLIRIFPNGTVLYALRITTTVACSMDLTKYPMDRQTCMLQLESWGYNVKDVV 183

  Fly   206 MYWK--PTPVRGVEDAELPQFTIIGYETNDRKERLATGVYQRLSLSFKLQRNIGYFVFQTYLPSI 268
            .||.  ...|.|::..:|.|:|:..:.|::.:....||.|.:|...|||:|:|.||:.:||:||.
Zfish   184 FYWTRGNQSVSGLDHLQLAQYTLEDHYTSESEAVYETGNYPKLIFHFKLKRSILYFILETYVPSS 248

  Fly   269 LIVMLSWVSFWINHEATSARVALGITTVLTMTTISTGVRSSLPRIS-YVKAIDIYLVMCFVFVFA 332
            .:|:||||||||:..:..||:.:|:||||||||:..|.|:|||..: ::||||:||.:||.|:|.
Zfish   249 ALVVLSWVSFWISQSSVPARICIGVTTVLTMTTLMMGARTSLPNANCFIKAIDVYLGICFSFIFG 313

  Fly   333 ALLEYA-----------AVNYTYWGKRAKKKIKKVKECCPG----KIGKSERSETCSTTEDIIEL 382
            ||:|||           |.|...:|:..:::..::......    .:...:|.|..|
Zfish   314 ALIEYAVAHFCTLHQPNAANAYMYGQEMQEREDEMNGIVTSFGSHALRARKREEMLS-------- 370

  Fly   383 QDVRMSPIPSLRRGTYNATLDSIGTETMNLGKFPPSFRITRNYGTGHSQLRRRAQRGISTRPRML 447
                       |.|:.|....|...|.::..:  |..|.|:        ...||:|.|    |.|
Zfish   371 -----------RMGSVNNPTPSESKEDVSSSQ--PQTRCTK--------CMSRARRII----RCL 410

  Fly   448 HALKRGASAIKATIPKIKDVNIIDKYSRMIFPISFLAFNLGYWLFYI 494
            :..            |:::.:.||.|||:.||:||:..||.||.:|:
Zfish   411 YCC------------KVENPHYIDNYSRLTFPLSFVIINLLYWTYYL 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	187/495 (38%)
		Neur_chan_LBD	47..256	CDD:280998	96/210 (46%)
		Neur_chan_memb	263..490	CDD:280999	76/242 (31%)
gabrz	NP_001108214.2	LIC	26..444	CDD:273305	180/475 (38%)
gabrz	NP_001108214.2	LGIC_ECD_GABAAR_pi	54..235	CDD:349805	88/193 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D226476at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920