DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lcch3 and LOC561083

DIOPT Version :9

Sequence 1:	NP_996469.1	Gene:	Lcch3 / 32554	FlyBaseID:	FBgn0010240	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	XP_009295726.1	Gene:	LOC561083 / 561083	-ID:	-	Length:	471	Species:	Danio rerio

Alignment Length:	477	Identity:	187/477 - (39%)
Similarity:	269/477 - (56%)	Gaps:	73/477 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 RKDVLAGRLENVTQTISNILQGYDIRLRPNFGGEPLHVGMDLTIASFDAISEVNMDYTITMYLNQ 93
            |||.....|....|.:.  ::.:|..:||.|||..:.||:|:.:.|.|:|||||||:|:|:||..
Zfish    55 RKDSTKSLLIKTEQLLR--IEDHDFAMRPAFGGSAIPVGIDVQVESIDSISEVNMDFTMTLYLRH 117

  Fly    94 YWRDERLAF---NIFGQYFDDENDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKL 155
            ||:||||||   |...:.||              |...:|||.||.||.:.|.||:||.|..|.:
Zfish   118 YWKDERLAFPSSNNLSRTFD--------------GRLVKKIWKPDVFFVHSKRSFIHDTTMENIM 168

  Fly   156 VRLGGDGAVTYGMRFTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYWKPTPVRG----- 215
            :|:..||.:.|.:|.|.|..|.||...:|||:|||::|:|||.|..:|:::|||    .|
Zfish   169 LRVYPDGNILYSVRITVTSLCSMDFSRFPLDTQNCSLELESYAYNENDLMLYWK----NGNDSLR 229

  Fly   216 VEDAELPQFTIIGYETNDRKERLA----TGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWV 276
            .::..|.||.|..:..:   ..||    ||.|.||.::|.|:|:|.:|:.|||.|::|:|:||||
Zfish   230 TDEIALSQFFIEEFHVS---HGLALYSSTGWYNRLYINFILRRHIFFFMLQTYFPTMLMVVLSWV 291

  Fly   277 SFWINHEATSARVALGITTVLTMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVN 341
            ||||:..|..|||:|||||||||:||.|||.:|:|::|||||:|:||...|:|||..::||||||
Zfish   292 SFWIDRRAVPARVSLGITTVLTMSTIITGVSTSMPQVSYVKAVDVYLWTSFLFVFLTVIEYAAVN 356

  Fly   342 YTYWGKRAKKKIKKVKECCPGKIGKSERSETCSTTEDIIELQDVRMSPIPSLRRGTYNATLDSIG 406
            |.    ..|:::||:|:.   ||.:.:.|:..: .:.....||:.:|..|.|.....:..:.|..
Zfish   357 YF----TTKEEMKKLKQL---KISEYDASQAMA-FDGCFHDQDIELSSFPRLSDLNADTCVSSRN 413

  Fly   407 TETMNLGKFPPSFRITRNYGTGHSQLRRRAQRGISTRPRMLHALKRGASAIKATIPKIKDVNIID 471
            :.|.:|   ||..      ||   :||||.    |.|..:.|.:.....              ||
Zfish   414 STTADL---PPVL------GT---RLRRRR----SIRQSVNHIINNSYK--------------ID 448

  Fly   472 KYSRMIFPISFLAFNLGYWLFY 493
            .|||:.||::::.|||.||..|
Zfish   449 SYSRICFPLAYVLFNLIYWSIY 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	186/475 (39%)
		Neur_chan_LBD	47..256	CDD:280998	88/220 (40%)
		Neur_chan_memb	263..490	CDD:280999	88/226 (39%)
LOC561083	XP_009295726.1	Neur_chan_LBD	67..470	CDD:332142	182/463 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D226476at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.020