Protein Alignment Lcch3 and GABRQ

DIOPT Version :9

• Sequence 1: NP_996469.1
• Gene: Lcch3 / 32554
• FlyBaseID: FBgn0010240
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_061028.3
• Gene: GABRQ / 55879
• HGNCID: 14454
• Length: 632
• Species: Homo sapiens
• Alignment Length: 594
• Identity: 176/594 - (29%)
• Similarity: 284/594 - (47%)
• Gaps: 160/594 - (26%)

  Fly    40 VTQTISNILQGYDIRLRPNFGGEPLHVGMDLTIASFDAISEVNMDYTITMYLNQYWRDERLAFNI 104
            |.:.:..:|..||:||||||||.|:.|.:.:.:.|.:.|||:||||||||:.:|.|:|.|||
Human    59 VQKILDRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWKDSRLA--- 120

  Fly   105 FGQYFDDENDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKLVRLGGDGAVTYGMR 169
               |::...:      |||.....||:||||.:|.|.|::|:||||..|::.:|..||.|.||:|
Human   121 ---YYETTLN------LTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGIR 176

  Fly   170 FTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYW--KPTPVRGVEDAELPQFTIIGYETN 232
            .|||.||.:|||.:|:|.|.|.:.:|||||||.|::::|  ....:...|:..:||||.:|....
Human   177 LTTTAACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFTFLGRTIT 241

  Fly   233 DRKERLATGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHEATSARVALGITTVL 297
            .::....||.|.||.|.|::||.:..::.|.|.|::|..:.||:|||:|:::::|||.:|:|::|
Human   242 SKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSSAARVTIGLTSML 306

  Fly   298 TMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVNYTYWGKRAKKKIKKVKE---- 358
            .:|||.:.:|..||.||.:||||||:::|..|||.:||||..:||.::.:..:::.::.:.
Human   307 ILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLFYSRGPRRQPRRHRRPRRV 371

  Fly   359 -------------------------------------CCPGKIGK----SERSETCSTTEDIIEL 382
                                                 ..|..:|.    ||::: .:|:|.:..|
Human   372 IARYRYQQVVVGNVQDGLINVEDGVSSLPITPAQAPLASPESLGSLTSTSEQAQ-LATSESLSPL 435

  Fly   383 QDV----------RMSPIPS----------LRRGTYNATLDSIGTETMNLGKFPPSFRITRNYGT 427
            ..:          .:|.:||          :|...:.|....|.||..|..: .....:|.::..
Human   436 TSLSGQAPLATGESLSDLPSTSEQARHSYGVRFNGFQADDSIIPTEIRNRVE-AHGHGVTHDHED 499

  Fly   428 GHSQLR--RRAQRGISTRPRMLHALKRGAS----------------AIKAT-------------- 460
            .:..|.  .|...|.|.:| |||..::|..                |||..
Human   500 SNESLSSDERHGHGPSGKP-MLHHGEKGVQEAGWDLDDNNDKSDCLAIKEQFKCDTNSTWGLNDD 563

  Fly   461 ----------------------------------------IPKIKDVNIIDKYSRMIFPISFLAF 485
                                                    :||      :||:||.:||::|..|
Human   564 ELMAHGQEKDSSSESEDSCPPSPGCSFTEGFSFDLFNPDYVPK------VDKWSRFLFPLAFGLF 622

  Fly   486 NLGYWLFYI 494
            |:.||::::
Human   623 NIVYWVYHM 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	176/591 (30%)
		Neur_chan_LBD	47..256	CDD:280998	93/210 (44%)
		Neur_chan_memb	263..490	CDD:280999	79/363 (22%)
GABRQ	NP_061028.3	Neur_chan_LBD	60..>353	CDD:332142	133/304 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	410..458		10/48 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	491..523		9/32 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D226476at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920