DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lcch3 and gabra4

DIOPT Version :9

Sequence 1:	NP_996469.1	Gene:	Lcch3 / 32554	FlyBaseID:	FBgn0010240	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001017822.1	Gene:	gabra4 / 550520	ZFINID:	ZDB-GENE-050417-360	Length:	557	Species:	Danio rerio

Alignment Length:	563	Identity:	173/563 - (30%)
Similarity:	268/563 - (47%)	Gaps:	93/563 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTCFTRVGVSCGLFFFLLGAQLQLIRCIRKDVLAGRL--------ENVTQTISNILQGYDIRLRP 57
            :|......:|..|:|..:.|      ||::  ::|::        ||.|:.:..:|.|||.||||
Zfish     9 VTAMYPTSISTLLYFLCVAA------CIKR--ISGQIRKDEKLYPENFTRILDRLLDGYDNRLRP 65

  Fly    58 NFGGEPLHVGMDLTIASFDAISEVNMDYTITMYLNQYWRDERLAFNIFGQYFDDENDDGISDVLT 122
            .|||....|..|:.:.||..:|:|.|:||:.::..|.|.|.||.:            :|..::|.
Zfish    66 GFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWVDRRLRY------------EGPVEILR 118

  Fly   123 LSGDFAEKIWVPDTFFANDKNSFLHDVTERNKLVRLGGDGAVTYGMRFTTTLACMMDLHYYPLDS 187
            |:.....|:|.|||||.|.|.|..|::|..|:|.|:..:|.:.|.||.|.:..|.|.|..:|:|.
Zfish   119 LNNLMVTKVWTPDTFFRNGKRSVAHNMTAPNRLFRIMKNGTILYTMRLTISAECPMRLVNFPMDG 183

  Fly   188 QNCTVEIESYGYTVSDVVMYWKPTPVRGV----EDAELPQFTIIGYETNDRKERLATGVYQRLSL 248
            .:|.::..||.|..::::..|...|...|    |.:.|.|:.:||...:....:..||.|..:::
Zfish   184 HSCPLKFGSYAYPKTEMIYTWTKGPQHSVEVPPESSSLVQYDLIGQTVSSETVKSITGEYVVMTV 248

  Fly   249 SFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHEATSARVALGITTVLTMTTISTGVRSSLPRI 313
            .|.|:|.:|||:.|||:|.|:.|:||.||||||.|:..||...||||||||||:|...|.|||::
Zfish   249 YFHLKRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKV 313

  Fly   314 SYVKAIDIYLVMCFVFVFAALLEYAAVNYTYWGKRAKKKIKKVKECCPGKIGKSERSETCSTTED 378
            ||..|:|.::.:||.|||:||:|:|||||....:..:.|.|:.|......: ||...:...|.|.
Zfish   314 SYATAMDWFIAVCFAFVFSALIEFAAVNYFTNAQAERAKRKQAKAAAAASV-KSSTGKNKDTEEV 377

  Fly   379 IIELQDVR-------------------------------MSPIPSLRRGTYNATLDSIGTETM-N 411
            :.:..|..                               .|..|:|   |..::..|.||.:. :
Zfish   378 LQQNSDTNGNLRKRVNSNIQPQAESKKTQRTEASSKSGASSSKPTL---TSQSSSTSEGTSSFSS 439

  Fly   412 LGKFPPSFRITRNYGTGHSQLRRRAQRGISTRPRM---------------LHAL----------K 451
            ..:..||.....|.....|...:.......:.|.:               ||.|          |
Zfish   440 QSRLSPSSASQSNAAASSSSASKTTPPAPPSTPTVPDKPSPGTTPAGSAPLHHLLGPKLENIKKK 504

  Fly   452 RGASAIKATIPKIKDVNIIDKYSRMIFPISFLAFNLGYWLFYI 494
            ...:..:...|.....:.||:|:|::||:||.|||:.||:.|:
Zfish   505 EAKAQPQPAAPATGGASKIDEYARILFPVSFGAFNMVYWVVYL 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	169/546 (31%)
		Neur_chan_LBD	47..256	CDD:280998	71/212 (33%)
		Neur_chan_memb	263..490	CDD:280999	84/283 (30%)
gabra4	NP_001017822.1	Neur_chan_LBD	49..256	CDD:280998	72/218 (33%)
gabra4	NP_001017822.1	Neur_chan_memb	263..543	CDD:280999	84/283 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810