DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lcch3 and glrbb

DIOPT Version :9

Sequence 1:	NP_996469.1	Gene:	Lcch3 / 32554	FlyBaseID:	FBgn0010240	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	XP_021336678.1	Gene:	glrbb / 445193	ZFINID:	ZDB-GENE-040801-106	Length:	502	Species:	Danio rerio

Alignment Length:	505	Identity:	168/505 - (33%)
Similarity:	258/505 - (51%)	Gaps:	73/505 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GAQLQLIRCIRKDVLAGRLENVTQTISN-ILQGYDIRLRPNFGGEPLHVGMDLTIASFDAISEVN 82
            |.|:.....:..:.||....|.|..|.| :|..||.|:||||.|.|:...:::.|.||.:|.|..
Zfish    42 GKQVYCPSQLSSEDLARVPANSTSNILNKLLITYDPRIRPNFKGIPVEDRVNIFINSFGSIQETT 106

  Fly    83 MDYTITMYLNQYWRDERLAFNIFGQYFDDENDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLH 147
            |||.:.::|.|.|.|.||..          ..|..||.||:.....:.:|.||.||||:|::..|
Zfish   107 MDYRVNIFLRQRWNDPRLRL----------PQDFKSDSLTVDPKMFKCLWKPDLFFANEKSANFH 161

  Fly   148 DVTERNKLVRLGGDGAVTYGMRFTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYWKP-T 211
            |||:.|.|:.:..:|.|...||.:.||:|.:||..:|:|:|.|.:::||:|||..|:...|:. .
Zfish   162 DVTQENILLFIFRNGDVLISMRLSVTLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLQFMWQSGD 226

  Fly   212 PVRGVEDAELPQFTI----IGYETNDRKERLATGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVM 272
            ||: :::..||||.|    |.| .|..|....||.|..:.:.|.|:|.:|:::...|.|::|||:
Zfish   227 PVQ-MDEIALPQFDIKQEDIEY-GNCTKYYAGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVV 289

  Fly   273 LSWVSFWINHEATSARVALGITTVLTMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEY 337
            |||:|||||.:|::|||.|||.:||::::..|.:.|.||::||||||||:|:.|.:|.||:|:||
Zfish   290 LSWLSFWINPDASAARVPLGILSVLSLSSECTSLASELPKVSYVKAIDIWLIACLLFGFASLVEY 354

  Fly   338 AAVNYTYWGKRAKKKIKKVKECCPGKIGKSERSETCSTTEDII-------------ELQDVRMSP 389
            |.|       :......|:.|....||...|::|..:..::.|             ::.:.|...
Zfish   355 AVV-------QVMLNSPKLLEAERAKIATKEKAEGKTPAKNTINGMGSTPIHVSTLQVTETRCKK 412

  Fly   390 I----PSLRRGTYNATLDSIGTETMNLGKFPPSFRITR--NYG----TGHSQLRRRAQRGISTRP 444
            :    ..||...::.           :|..|..|.::.  .||    .|.:..:.:|:......|
Zfish   413 VCTSKSDLRTNDFSI-----------VGSLPRDFELSNFDCYGKPIEVGSAFSKSQAKNNKKPPP 466

  Fly   445 RMLHALKRGASAIKATIPKIKDVNIIDKYSRMIFPISFLAFNLGYWLFYI 494
            .            |..||..  ...||.|:|.:||.|||.||:.||..|:
Zfish   467 P------------KPVIPSA--AKRIDLYARALFPFSFLFFNVIYWSVYL 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	167/502 (33%)
		Neur_chan_LBD	47..256	CDD:280998	80/213 (38%)
		Neur_chan_memb	263..490	CDD:280999	76/249 (31%)
glrbb	XP_021336678.1	Neur_chan_LBD	53..501	CDD:332142	165/491 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810