DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lcch3 and pHCl-2

DIOPT Version :9

Sequence 1:	NP_996469.1	Gene:	Lcch3 / 32554	FlyBaseID:	FBgn0010240	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001303470.1	Gene:	pHCl-2 / 43703	FlyBaseID:	FBgn0039840	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	479	Identity:	133/479 - (27%)
Similarity:	224/479 - (46%)	Gaps:	71/479 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 YDIRLRP---NFGGEPLHVGMDLTIASFDAISEVNMD-----YTITMYLNQYWRDERLAFNIFGQ 107
            ||..:.|   |..||  .|.||: .|.|......|:|     :|:...|...:.|.||||:   .
  Fly    85 YDRMVPPVVHNKDGE--EVPMDI-YARFYIYVMKNLDSSDLQFTVQGLLQLRYLDPRLAFS---S 143

  Fly   108 YFDDENDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKLVRLGGDGAVTYGMRFTT 172
            |..:.....:.:     .:..:.:|||..|..|::.|.:...:.:::|..:..:|.|....|...
  Fly   144 YLPNRRQPIMGE-----SELKKMLWVPHIFLTNEQASTVLGTSAKDELTSIYPNGTVLTSTRLQA 203

  Fly   173 TLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYWK-PTPVRGVEDAELPQFTIIG--YETNDR 234
            ||.|.|:...:|.|.|.|...:||:.|..:.|.::|: ..||...:..:|.::.:||  |..:.|
  Fly   204 TLYCWMNFQKFPFDEQKCKTTLESWMYNTTLVQLHWETDNPVSFDKQLQLTEYNLIGSLYNESIR 268

  Fly   235 KERLA-------TGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHEATSARVALG 292
            ....:       .|.|..:|.:..|.|.:||:|...:||||:||.:||||||:..:.|.||..||
  Fly   269 VSNESYMSHGSLEGNYSIISFTVLLTREVGYYVIDYFLPSIMIVTISWVSFWLQADQTPARTTLG 333

  Fly   293 ITTVLTMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVNYTYWGKRAKKKIKKVK 357
            .||:|:..|:|....::|.::|||...:::.::|.:|:|.:|:|:|.|| |.|.:....::||
  Fly   334 CTTLLSFITLSLSQENNLMKVSYVTMSEVWFLVCTIFIFGSLVEFAFVN-TIWRRNNDLQLKK-- 395

  Fly   358 ECCPGKIGKSERSETCSTTEDIIELQDVRMSPIPSL---RRGTY---NATLDSIGTETMNLGKFP 416
                            .||:.|     |:.:.:|.|   ||..|   ::|:.::.|.:|:....|
  Fly   396 ----------------RTTKYI-----VKSTFVPHLKKHRRHGYRRTDSTMSTMSTTSMDKTCGP 439

  Fly   417 PSFRIT--------RNYGTGHSQLRRRAQRGISTRPRMLHALKRGASAIKATIPKIKDVNI-IDK 472
            .:..||        .:.....|.:....|...||......:.::.|.......|  |:|:: ||:
  Fly   440 NNTVITIETPIIIGGSLSREDSAISLDEQDETSTSESSDSSKEKPAQTFATMTP--KEVSLWIDR 502

  Fly   473 YSRMIFPISFLAFNLGYW-LFYIL 495
            ..|.:||:||:.||..:| |.|.|
  Fly   503 KMRFVFPLSFIVFNALFWTLVYCL 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	131/475 (28%)
		Neur_chan_LBD	47..256	CDD:280998	56/222 (25%)
		Neur_chan_memb	263..490	CDD:280999	70/241 (29%)
pHCl-2	NP_001303470.1	LIC	46..522	CDD:273305	130/473 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447279
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840