DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lcch3 and GluClalpha

DIOPT Version :9

Sequence 1:	NP_996469.1	Gene:	Lcch3 / 32554	FlyBaseID:	FBgn0010240	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001287408.1	Gene:	GluClalpha / 42350	FlyBaseID:	FBgn0024963	Length:	463	Species:	Drosophila melanogaster

Alignment Length:	479	Identity:	152/479 - (31%)
Similarity:	237/479 - (49%)	Gaps:	75/479 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 ENVTQTISNILQG--YDIRLRP---NFGGEPLHVGMDLTIASFDAISEVNMDYTITMYLNQYWRD 97
            |...:.:..||..  ||.|:||   |....|..|.:::.:.|...|.:|.|:|::.:...:.|.|
  Fly    31 EKEKKVLDQILGAGKYDARIRPSGINGTDGPAVVRVNIFVRSISKIDDVTMEYSVQLTFREQWTD 95

  Fly    98 ERLAFNIFGQYFDDENDD--GISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKLVRLGG 160
            |||.|           ||  |....|||:.  |.::|:||.||:|:|....|::...|..:|:..
  Fly    96 ERLKF-----------DDIQGRLKYLTLTE--ANRVWMPDLFFSNEKEGHFHNIIMPNVYIRIFP 147

  Fly   161 DGAVTYGMRFTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYWKP-TPVRGVEDAELPQF 224
            :|:|.|.:|.:.||||.|:|..||||.|.|::.:.|||:|.:|:|..||. .||:.|::..||:|
  Fly   148 NGSVLYSIRISLTLACPMNLKLYPLDRQICSLRMASYGWTTNDLVFLWKEGDPVQVVKNLHLPRF 212

  Fly   225 TIIGYETNDRKERLATGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHEATSARV 289
            |:..:.|:....:..||.|..|.:....:|...|::.|.|:|..::|::||||||::..|..|||
  Fly   213 TLEKFLTDYCNSKTNTGEYSCLKVDLLFKREFSYYLIQIYIPCCMLVIVSWVSFWLDQGAVPARV 277

  Fly   290 ALGITTVLTMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVNYTYWGKRAKKKIK 354
            :||:||:|||.|.::|:.:|||.:||.||||::..:|..|||.||||:|.|||.  .:....|..
  Fly   278 SLGVTTLLTMATQTSGINASLPPVSYTKAIDVWTGVCLTFVFGALLEFALVNYA--SRSGSNKAN 340

  Fly   355 KVKECCPGKIGKSERSETCSTTEDIIELQDVRMSPIPSLRRGTYNATLDSIGTETMNLGKFPPSF 419
            ..||    .:.|..|                      .|.:.:.:|..|.:.|::      ..:|
  Fly   341 MHKE----NMKKKRR----------------------DLEQASLDAASDLLDTDS------NATF 373

  Fly   420 RITRNYGTGHSQ-------------LRRRAQRGISTR-PRMLHALKRGASAIKATIPKIKDVNII 470
            .:...:..|..|             |.:|.|..:..: |:..:..|...|.......:      |
  Fly   374 AMASQFARGGGQQKPLVRHPGDPLALEKRLQCEVHMQAPKRPNCCKTWLSKFPTRSKR------I 432

  Fly   471 DKYSRMIFPISFLAFNLGYWLFYI 494
            |..||:.||:.|..|||.||..|:
  Fly   433 DVISRITFPLVFALFNLVYWSTYL 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	151/476 (32%)
		Neur_chan_LBD	47..256	CDD:280998	75/216 (35%)
		Neur_chan_memb	263..490	CDD:280999	71/240 (30%)
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	151/476 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447357
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41384at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950