Protein Alignment Lcch3 and nAChRalpha4

DIOPT Version :10

• Sequence 1: NP_996469.1
• Gene: Lcch3 / 32554
• FlyBaseID: FBgn0010240
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Alignment Length: 479
• Identity: 92/479 - (19%)
• Similarity: 185/479 - (38%)
• Gaps: 73/479 - (15%)

  Fly    46 NILQGYDIRLRPNFG-GEPLHVGMDLTIASFDAISEVNMDYTITMYLNQYWRDERLAFNIFGQYF 109
            ::|..|:..:||... .:.|.|.:.|.::....::..|...|..:::.|.|.|.:|.:
  Fly    18 DLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRW------- 75

  Fly   110 DDENDDGISDVLTLSGDFAEKIWVPD-TFFANDKNSFLHDVTERNKLVRLGGDGAVTYGMRFTTT 173
             :..:.|...:|.:..|   .||.|| ..:.|...:|  :||...| ..:..:|.|.:.......
  Fly    76 -EPKEYGGVHMLHVPSD---HIWRPDIVLYNNADGNF--EVTLATK-ATIYSEGLVEWKPPAIYK 133

  Fly   174 LACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYWKPTPVRGVEDAELPQFTIIGYETND----- 233
            .:|.:|:.|:|.|.|.|.::..|:.|....|       .:|.:::.:......:|.:.::
  Fly   134 SSCEIDVEYFPFDEQTCVLKFGSWTYDGFKV-------DLRHMDEQQGSNVVAVGVDLSEFYMSV 191

  Fly   234 ----------RKERLAT---GVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHEAT 285
                      |.|:..|   ..|..::.:..::|...::.....:|.:.|..|:.::|::..: :
  Fly   192 EWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSD-S 255

  Fly   286 SARVALGITTVLTMTTISTGVRSSLPRIS-YVKAIDIYLVMCFVFVFAAL-LEYAAVNYTYWGKR 348
            ..:|.|.|:.::::......|...:|..| .|..:..||:...:.|..:: :....:|..:...:
  Fly   256 GEKVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQ 320

  Fly   349 AKKKIKKVK----ECCPGKIGKSERSETCSTTEDIIELQDVRMSPIPSLRRGTYNAT-LDSIGTE 408
            ..|....||    :..|..:.....:....|::  :.|:|......|     .|:|| :|.:.:.
  Fly   321 THKMAPWVKRVFIDFLPAFLFIKRPTYNFETSK--LLLKDTHACFYP-----YYSATNIDRLVSS 378

  Fly   409 TMN--LGKFPPSFRITRNYGTGHS--------QLRRRAQRGISTRPRMLHALKRGASAIKATI-- 461
            ..|  |.|...|..||.|...|.|        .|...:...|:..|.|    ..|...:|:.|
  Fly   379 GYNNSLPKEDLSQSITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDM----DIGPLGMKSPILN 439

  Fly   462 -PKIKDVNIIDKYSRMIFPISFLA 484
             |.......:.|..:..|.:.|:|
  Fly   440 NPAFSHSKCLPKIHKSCFCVRFIA 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	92/479 (19%)
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:455710	92/479 (19%)
		LGIC_ECD_nAChR_proto_alpha-like	11..229	CDD:349832	44/231 (19%)
		Cys-loop	136..150	CDD:349832	6/13 (46%)