Protein Alignment Lcch3 and nAChRalpha6

DIOPT Version :10

• Sequence 1: NP_996469.1
• Gene: Lcch3 / 32554
• FlyBaseID: FBgn0010240
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Alignment Length: 556
• Identity: 106/556 - (19%)
• Similarity: 202/556 - (36%)
• Gaps: 144/556 - (25%)

  Fly    10 SCGLFFFLLGAQLQLIRCIRKDVLAGRLENVTQTISNILQGYDIRLRPNFG-GEPLHVGMDLTIA 73
            |..||..|      :...|.|:...|..|.  :.::::|..|:...||... .|||.|...||:.
  Fly     8 SLSLFVLL------IFLAIIKESCQGPHEK--RLLNHLLSTYNTLERPVANESEPLEVKFGLTLQ 64

  Fly    74 SFDAISEVNMDYTITMYLNQYWRDERLAFNIFGQYFDDENDDGISDV-LTLSGDFAEKIWVPDTF 137
            ....:.|.|...|...:||..|.|..|.:|       :....|:.|: :|     ..|:|.||..
  Fly    65 QIIDVDEKNQILTTNAWLNLEWNDYNLRWN-------ETEYGGVKDLRIT-----PNKLWKPDVL 117

  Fly   138 FANDKNSFLHDVTERNKLVRLGGDGAVTYGMRFTTTLACMMDLHYYPLDSQNCTVEIESYGYTVS 202
            ..|..:.........|.:|:..|.........|.:|  |.:|:.::|.|.|:|.::..|:.|..:
  Fly   118 MYNSADEGFDGTYHTNIVVKHNGSCLYVPPGIFKST--CKIDITWFPFDDQHCEMKFGSWTYDGN 180

  Fly   203 --DVVMYWKPTPVRGVEDAELPQFTIIGYETNDRKERLA------TGVYQ-------RLSLSFKL 252
              |:|:       ...:..:|..|.     ||.....||      |.||.       .::.:.::
  Fly   181 QLDLVL-------NSEDGGDLSDFI-----TNGEWYLLAMPGKKNTIVYACCPEPYVDITFTIQI 233

  Fly   253 QRNIGYFVFQTYLPSILIVMLSWVSFWINHEATSARVALGITTVLTMTTISTGVRSSLPR----- 312
            :|...|:.|...:|.:||..::.:.|.:..: :..::.||:|.:|::|.....|..|:|.
  Fly   234 RRRTLYYFFNLIVPCVLISSMALLGFTLPPD-SGEKLTLGVTILLSLTVFLNLVAESMPTTSDAV 297

  Fly   313 ----ISYVKAIDIYLVM--------------------CFVFVFAA--LLEYAAVNYTY------- 344
                ::.:.::.::|.:                    |.:|:.|:  :|....:||.:
  Fly   298 PLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHE 362

  Fly   345 ---WGK--------------RAKKKIKKVKECCPGKIGKSERSETCSTT--EDIIELQDVRMSPI 390
               |.|              |..:||.:.......::.:.|..|..|.:  .:::::.|.
  Fly   363 MPPWIKSVFLQWLPWILRMGRPGRKITRKTILLSNRMKELELKERSSKSLLANVLDIDDD----- 422

  Fly   391 PSLRRGTYNATLDSIGTETMNLGKFPPSFRITRNYGTGHSQLRRRAQRGISTRPRMLHALKRGAS 455
               .|.|.:.:..:||:..        ||        |...........|....:.||.:.:...
  Fly   423 ---FRHTISGSQTAIGSSA--------SF--------GRPTTVEEHHTAIGCNHKDLHLILKELQ 468

  Fly   456 AIKATIPKIKD-----------VNIIDKYSRMIFPI 480
            .|.|.:.|..|           ..::|::..::|.:
  Fly   469 FITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTL 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	103/551 (19%)
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	105/553 (19%)
		LGIC_ECD_nAChR	55..236	CDD:349798	45/206 (22%)
		Cys-loop	154..168	CDD:349798	5/13 (38%)