DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lcch3 and Gabra1

DIOPT Version :9

Sequence 1:	NP_996469.1	Gene:	Lcch3 / 32554	FlyBaseID:	FBgn0010240	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_899155.1	Gene:	Gabra1 / 29705	RGDID:	61855	Length:	455	Species:	Rattus norvegicus

Alignment Length:	479	Identity:	170/479 - (35%)
Similarity:	239/479 - (49%)	Gaps:	81/479 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 KDVLAGRLENVTQTISNILQGYDIRLRPNFGGEPLHVGMDLTIASFDAISEVNMDYTITMYLNQY 94
            :|.|.......|:.:..:|.|||.||||..|.....|..|:.:.||..:|:.:|:|||.::..|.
  Rat    31 QDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQS 95

  Fly    95 WRDERLAFNIFGQYFDDENDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKLVRLG 159
            |:||||.|.            |...||.|:...|.|||.|||||.|.|.|..|::|..|||:|:.
  Rat    96 WKDERLKFK------------GPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIT 148

  Fly   160 GDGAVTYGMRFTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYWKPTPVRGVEDAE---- 220
            .||.:.|.||.|....|.|.|..:|:|:..|.::..||.||.::||..|...|.|.|..||
  Rat   149 EDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSR 213

  Fly   221 LPQFTIIGYETNDRKERLATGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHEAT 285
            |.|:.::|...:....:.:||.|..::..|.|:|.|||||.|||||.|:.|:||.||||:|.|:.
  Rat   214 LNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESV 278

  Fly   286 SARVALGITTVLTMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVN------YTY 344
            .||...|:||||||||:|...|:|||:::|..|:|.::.:|:.|||:||:|:|.||      |.:
  Rat   279 PARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAW 343

  Fly   345 WGKR-AKKKIKKVKECCPGKIGKSERSETCSTTEDIIELQDVRMSPIPSLRR-GTYNATLDSIGT 407
            .||. ..:|.||||:                                |.::: .||..|..|.
  Rat   344 DGKSVVPEKPKKVKD--------------------------------PLIKKNNTYAPTATSY-- 374

  Fly   408 ETMNLGKFPPSFRITRNYGTGHSQLRRRAQRGISTRPRMLHALKRGASAIKATIPK--IKDVNII 470
             |.||.:..|          |.:.:.:.|    :..|      |......|...||  ...|:.|
  Rat   375 -TPNLARGDP----------GLATIAKSA----TIEP------KEVKPETKPPEPKKTFNSVSKI 418

  Fly   471 DKYSRMIFPISFLAFNLGYWLFYI 494
            |:.||:.||:.|..|||.||..|:
  Rat   419 DRLSRIAFPLLFGIFNLVYWATYL 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	169/476 (36%)
		Neur_chan_LBD	47..256	CDD:280998	80/212 (38%)
		Neur_chan_memb	263..490	CDD:280999	78/236 (33%)
Gabra1	NP_899155.1	LIC	7..441	CDD:273305	169/476 (36%)
		LGIC_ECD_GABAAR_A1	55..248	CDD:349835	75/204 (37%)
		Cys-loop	165..179	CDD:349835	5/13 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810