DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lcch3 and Gabrr1

DIOPT Version :9

Sequence 1:	NP_996469.1	Gene:	Lcch3 / 32554	FlyBaseID:	FBgn0010240	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_058987.3	Gene:	Gabrr1 / 29694	RGDID:	61900	Length:	480	Species:	Rattus norvegicus

Alignment Length:	453	Identity:	178/453 - (39%)
Similarity:	258/453 - (56%)	Gaps:	62/453 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 LQGYDIRLRPNFGGEPLHVGMDLTIASFDAISEVNMDYTITMYLNQYWRDERLAFNIFGQYFDDE 112
            :..:|..:||.|||..:.||:|:.:.|.|:||||:||:|:|:||..||:||||:|         .
  Rat    82 IDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSF---------P 137

  Fly   113 NDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKLVRLGGDGAVTYGMRFTTTLACM 177
            :.:.:|  :|..|...:||||||.||.:.|.||:||.|..|.::|:..||.|.|.:|.|.|..|.
  Rat   138 STNNLS--MTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCN 200

  Fly   178 MDLHYYPLDSQNCTVEIESYGYTVSDVVMYWKP--TPVRGVEDAELPQFTIIGYETNDRKERLA- 239
            ||...:|||:|.|::|||||.||..|:::|||.  ..::..|...|.||.|..:.|.   .:||
  Rat   201 MDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTT---TKLAF 262

  Fly   240 ---TGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHEATSARVALGITTVLTMTT 301
               ||.|.||.::|.|:|:|.:|:.|||.|:.|:||||||||||:..|..|||.|||||||||:|
  Rat   263 YSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMST 327

  Fly   302 ISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVNY-TYWGKRAKKKIKKVKECCPGKIG 365
            |.|||.:|:||:||:||:||||.:.|||||.::|||||||| |...:|.::|:::...|
  Rat   328 IITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKERKLREKISC------ 386

  Fly   366 KSERSETCSTTEDIIELQDVRMSPIPSLRRGTYNATLDSIGTETMNLGKFPPSFRITRNYGTGHS 430
                  ||...:....:.|...|          :..::.:|......|:.|....:.....:...
  Rat   387 ------TCGLPQPRGVMLDSSYS----------DGEVNDLGGYMPENGEKPDRMMVQLTLASERG 435

  Fly   431 QLRRRAQRGISTRPRMLHALKRGASAIKATIPKIKDVNIIDKYSRMIFPISFLAFNLGYWLFY 493
            ..:|::|||.....|:                   :.:.||||||:|||.:::.|||.||..:
  Rat   436 SPQRKSQRGSYVSMRI-------------------NTHAIDKYSRIIFPAAYILFNLIYWSIF 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	178/451 (39%)
		Neur_chan_LBD	47..256	CDD:280998	89/213 (42%)
		Neur_chan_memb	263..490	CDD:280999	84/227 (37%)
Gabrr1	NP_058987.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..67
		LIC	76..479	CDD:273305	178/451 (39%)
		LGIC_ECD_GABAAR_rho	97..282	CDD:349806	83/198 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910