DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lcch3 and Gabra2

DIOPT Version :9

Sequence 1:	NP_996469.1	Gene:	Lcch3 / 32554	FlyBaseID:	FBgn0010240	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	XP_017454595.1	Gene:	Gabra2 / 289606	RGDID:	61856	Length:	504	Species:	Rattus norvegicus

Alignment Length:	501	Identity:	166/501 - (33%)
Similarity:	246/501 - (49%)	Gaps:	82/501 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SCGLFFFLL------GAQLQLIRCIRKDVLAGRLENVTQTISNILQGYDIRLRPNFGGEPLHVGM 68
            :|.::|.||      .|:|.|.. |::|.....:...|:.:..:|.|||.||||..|.....|..
  Rat    60 TCNVWFPLLVLLVWNPARLVLAN-IQEDEAKNNITIFTRILDRLLDGYDNRLRPGLGDSITEVFT 123

  Fly    69 DLTIASFDAISEVNMDYTITMYLNQYWRDERLAFNIFGQYFDDENDDGISDVLTLSGDFAEKIWV 133
            ::.:.||..:|:.:|:|||.::..|.|:||||.|.            |..::|.|:...|.|||.
  Rat   124 NIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFK------------GPMNILRLNNLMASKIWT 176

  Fly   134 PDTFFANDKNSFLHDVTERNKLVRLGGDGAVTYGMRFTTTLACMMDLHYYPLDSQNCTVEIESYG 198
            |||||.|.|.|..|::|..|||:|:..||.:.|.||.|....|.|.|..:|:|:.:|.::..||.
  Rat   177 PDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSCPLKFGSYA 241

  Fly   199 YTVSDVVMYWKPTPVRGVEDA----ELPQFTIIGYETNDRKERLATGVYQRLSLSFKLQRNIGYF 259
            ||.|:|...|.......|:.|    .|.|:.::|........:.:||.|..::..|.|:|.||||
  Rat   242 YTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYF 306

  Fly   260 VFQTYLPSILIVMLSWVSFWINHEATSARVALGITTVLTMTTISTGVRSSLPRISYVKAIDIYLV 324
            |.|||||.|:.|:||.||||:|.|:..||...|:||||||||:|...|:|||:::|..|:|.::.
  Rat   307 VIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIA 371

  Fly   325 MCFVFVFAALLEYAAVNY------TYWGKRAKKKIKKVKECCPGKIGKSERSETCSTTEDIIELQ 383
            :|:.|||:||:|:|.|||      .:.||......||.|                    ..:.:|
  Rat   372 VCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKKKEK--------------------GSVMIQ 416

  Fly   384 DVRMSPIPSLRRGTYNATLDSIGTETMNLGKFPPSFRITRNYGTGHSQLRRRAQRGISTRPRMLH 448
            :              ||...::.....||.|.|....|:::                :|.|....
  Rat   417 N--------------NAYAVAVANYAPNLSKDPVLSTISKS----------------ATTPEPNK 451

  Fly   449 ALKRGASAIKATIPKIKDVNIIDKYSRMIFPISFLAFNLGYWLFYI 494
            ..:...:..|.|   ...|:.||:.||::||:.|..|||.||..|:
  Rat   452 KPENKPAEAKKT---FNSVSKIDRMSRIVFPVLFGTFNLVYWATYL 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	164/493 (33%)
		Neur_chan_LBD	47..256	CDD:280998	75/212 (35%)
		Neur_chan_memb	263..490	CDD:280999	72/232 (31%)
Gabra2	XP_017454595.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810