Protein Alignment Lcch3 and GLRB

DIOPT Version :10

• Sequence 1: NP_996469.1
• Gene: Lcch3 / 32554
• FlyBaseID: FBgn0010240
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_000815.1
• Gene: GLRB / 2743
• HGNCID: 4329
• Length: 497
• Species: Homo sapiens
• Alignment Length: 476
• Identity: 166/476 - (34%)
• Similarity: 255/476 - (53%)
• Gaps: 52/476 - (10%)

  Fly    39 NVTQTISN-ILQGYDIRLRPNFGGEPLHVGMDLTIASFDAISEVNMDYTITMYLNQYWRDERLAF 102
            |.|..|.| :|..||.|:||||.|.|:.|.:::.|.||.:|.|..|||.:.::|.|.|.|.||..
Human    54 NSTSNILNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKL 118

  Fly   103 NIFGQYFDDENDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKLVRLGGDGAVTYG 167
                     .:|...||.||:.....:.:|.||.||||:|::..||||:.|.|:.:..||.|...
Human   119 ---------PSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVS 174

  Fly   168 MRFTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYWKP-TPVRGVEDAELPQFTI----I 227
            ||.:.||:|.:||..:|:|:|.|.:::||:|||..|:...|:. .||: :|...||||.|    |
Human   175 MRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQ-LEKIALPQFDIKKEDI 238

  Fly   228 GYETNDRKERLATGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHEATSARVALG 292
            .| .|..|....||.|..:.:.|.|:|.:|:::...|.|::|||:|||:|||||.:|::|||.||
Human   239 EY-GNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLG 302

  Fly   293 ITTVLTMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAV----NYTYWGKRAKKKI 353
            |.:||::.:..|.:.:.||::|||||:|::|:.|.:|.||:|:|||.|    |.....:..|.:|
Human   303 IFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRVEAEKARI 367

  Fly   354 KKVKECCPGKIGKSERSETCSTTEDIIELQDVRMSPIPSLRRGTYNATLDSIGTETMNLGKFPPS 418
            .|.:: ..||.|...:..|.:.|...:.:..:::......:..|..:.|.|  .:...:|..|..
Human   368 AKAEQ-ADGKGGNVAKKNTVNGTGTPVHISTLQVGETRCKKVCTSKSDLRS--NDFSIVGSLPRD 429

  Fly   419 FRITR----------NYGTGHSQLRRRAQRGISTRPRMLHALKRGASAIKATIPKIKDVNIIDKY 473
            |.::.          |.|.|.||.:.. ::....:|.:..|.||                 ||.|
Human   430 FELSNYDCYGKPIEVNNGLGKSQAKNN-KKPPPAKPVIPTAAKR-----------------IDLY 476

  Fly   474 SRMIFPISFLAFNLGYWLFYI 494
            :|.:||..||.||:.||..|:
Human   477 ARALFPFCFLFFNVIYWSIYL 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	165/473 (35%)
GLRB	NP_000815.1	LIC	43..496	CDD:455710	165/473 (35%)
		LGIC_ECD_GlyR_beta	79..265	CDD:349811	73/196 (37%)
		Cys-loop	183..197	CDD:349811	6/13 (46%)