DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lcch3 and GLRB

DIOPT Version :9

Sequence 1:NP_996469.1 Gene:Lcch3 / 32554 FlyBaseID:FBgn0010240 Length:496 Species:Drosophila melanogaster
Sequence 2:NP_000815.1 Gene:GLRB / 2743 HGNCID:4329 Length:497 Species:Homo sapiens


Alignment Length:476 Identity:166/476 - (34%)
Similarity:255/476 - (53%) Gaps:52/476 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 NVTQTISN-ILQGYDIRLRPNFGGEPLHVGMDLTIASFDAISEVNMDYTITMYLNQYWRDERLAF 102
            |.|..|.| :|..||.|:||||.|.|:.|.:::.|.||.:|.|..|||.:.::|.|.|.|.||..
Human    54 NSTSNILNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKL 118

  Fly   103 NIFGQYFDDENDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKLVRLGGDGAVTYG 167
                     .:|...||.||:.....:.:|.||.||||:|::..||||:.|.|:.:..||.|...
Human   119 ---------PSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVS 174

  Fly   168 MRFTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYWKP-TPVRGVEDAELPQFTI----I 227
            ||.:.||:|.:||..:|:|:|.|.:::||:|||..|:...|:. .||: :|...||||.|    |
Human   175 MRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQ-LEKIALPQFDIKKEDI 238

  Fly   228 GYETNDRKERLATGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHEATSARVALG 292
            .| .|..|....||.|..:.:.|.|:|.:|:::...|.|::|||:|||:|||||.:|::|||.||
Human   239 EY-GNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLG 302

  Fly   293 ITTVLTMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAV----NYTYWGKRAKKKI 353
            |.:||::.:..|.:.:.||::|||||:|::|:.|.:|.||:|:|||.|    |.....:..|.:|
Human   303 IFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRVEAEKARI 367

  Fly   354 KKVKECCPGKIGKSERSETCSTTEDIIELQDVRMSPIPSLRRGTYNATLDSIGTETMNLGKFPPS 418
            .|.:: ..||.|...:..|.:.|...:.:..:::......:..|..:.|.|  .:...:|..|..
Human   368 AKAEQ-ADGKGGNVAKKNTVNGTGTPVHISTLQVGETRCKKVCTSKSDLRS--NDFSIVGSLPRD 429

  Fly   419 FRITR----------NYGTGHSQLRRRAQRGISTRPRMLHALKRGASAIKATIPKIKDVNIIDKY 473
            |.::.          |.|.|.||.:.. ::....:|.:..|.||                 ||.|
Human   430 FELSNYDCYGKPIEVNNGLGKSQAKNN-KKPPPAKPVIPTAAKR-----------------IDLY 476

  Fly   474 SRMIFPISFLAFNLGYWLFYI 494
            :|.:||..||.||:.||..|:
Human   477 ARALFPFCFLFFNVIYWSIYL 497

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lcch3NP_996469.1 LIC 15..493 CDD:273305 165/473 (35%)
Neur_chan_LBD 47..256 CDD:280998 83/213 (39%)
Neur_chan_memb 263..490 CDD:280999 75/240 (31%)
GLRBNP_000815.1 LIC 43..496 CDD:273305 165/473 (35%)
LGIC_ECD_GlyR_beta 79..265 CDD:349811 73/196 (37%)
Strychnine-binding. /evidence=ECO:0000250|UniProtKB:O93430 247..253 2/5 (40%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3644
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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