Protein Alignment Lcch3 and GLRA2

DIOPT Version :9

• Sequence 1: NP_996469.1
• Gene: Lcch3 / 32554
• FlyBaseID: FBgn0010240
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_001112357.1
• Gene: GLRA2 / 2742
• HGNCID: 4327
• Length: 452
• Species: Homo sapiens
• Alignment Length: 505
• Identity: 189/505 - (37%)
• Similarity: 273/505 - (54%)
• Gaps: 87/505 - (17%)

  Fly     7 VGVSCGLF-FFLLGAQLQLIRCIRKDVLAGRLENVTQTISNIL-------QGYDIRLRPNFGGEP 63
            |.:...|| |||.....:...|...|..:|:..:.|.:.|:.|       .|||.|:||||.|.|
Human     6 VNILTALFAFFLETNHFRTAFCKDHDSRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPP 70

  Fly    64 LHVGMDLTIASFDAISEVNMDYTITMYLNQYWRDERLAFNIFGQYFDDENDDGISDVLTLSGDFA 128
            ::|..::.|.||.:::|..|||.:.::|.|.|.|.|||::   :|.||.        |.|.....
Human    71 VNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYS---EYPDDS--------LDLDPSML 124

  Fly   129 EKIWVPDTFFANDKNSFLHDVTERNKLVRLGGDGAVTYGMRFTTTLACMMDLHYYPLDSQNCTVE 193
            :.||.||.||||:|.:..||||..|||:|:..:|.|.|.:|.|.||:|.|||..:|:|.|.||::
Human   125 DSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQ 189

  Fly   194 IESYGYTVSDVVMYW-KPTPVRGVEDAELPQFTI-----IGYETNDRKERLATGVYQRLSLSFKL 252
            :||:|||::|::..| ...||:..|...||||.:     :||.|    :...||.:..:.:.|.|
Human   190 LESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCT----KHYNTGKFTCIEVKFHL 250

  Fly   253 QRNIGYFVFQTYLPSILIVMLSWVSFWINHEATSARVALGITTVLTMTTISTGVRSSLPRISYVK 317
            :|.:||::.|.|:||:|||:|||||||||.:|..|||||||||||||||.|:|.|:|||::||||
Human   251 ERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVK 315

  Fly   318 AIDIYLVMCFVFVFAALLEYAAVNYTYWGKRAKKKIKKVKECCPGKIGKSERSETCSTTEDIIEL 382
            ||||::.:|.:|||||||||||||:.   .|..|:..:::          .|.:..:..||:
Human   316 AIDIWMAVCLLFVFAALLEYAAVNFV---SRQHKEFLRLR----------RRQKRQNKEEDV--- 364

  Fly   383 QDVRMSPIPSLRRGTYNATLDSIGTETMNLGKFPPSFRITRNYGTGHSQLRRRAQRGISTRPRML 447
                      .|...:|.:                      .||.||.   .:.:.|.:.:....
Human   365 ----------TRESRFNFS----------------------GYGMGHC---LQVKDGTAVKATPA 394

  Fly   448 HAL----KRGASAIKATIPKIKDVNIIDKYSRMIFPISFLAFNLGYWLFY 493
            :.|    |.|.:..|..:.:.|.   ||..||..||::||.||:.||:.|
Human   395 NPLPQPPKDGDAIKKKFVDRAKR---IDTISRAAFPLAFLIFNIFYWITY 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	185/494 (37%)
		Neur_chan_LBD	47..256	CDD:280998	86/221 (39%)
		Neur_chan_memb	263..490	CDD:280999	86/230 (37%)
GLRA2	NP_001112357.1	LIC	46..441	CDD:273305	177/463 (38%)
		Strychnine-binding. /evidence=ECO:0000250|UniProtKB:O93430	236..241		2/4 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810