Protein Alignment Lcch3 and lgc-43

DIOPT Version :10

• Sequence 1: NP_996469.1
• Gene: Lcch3 / 32554
• FlyBaseID: FBgn0010240
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_001023062.1
• Gene: lgc-43 / 259591
• WormBaseID: WBGene00008076
• Length: 679
• Species: Caenorhabditis elegans
• Alignment Length: 439
• Identity: 101/439 - (23%)
• Similarity: 167/439 - (38%)
• Gaps: 114/439 - (25%)

  Fly    59 FGGEPLHVGMD---LTIASFDAISEVNMDYTITMYLNQYWRDERLAFNIFGQYFDDENDDGISDV 120
            |...|::|.:.   |.:|:||  ||: |::::.:.:...|.|.||..|.            ...:
 Worm   339 FNDIPVNVAVAFNFLYLANFD--SEM-MEFSMDVEMEFSWIDIRLVNNY------------TKPI 388

  Fly   121 LTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKLVRLGGDGAVTYGMRFTTTLACMMDLHYYPL 185
            ........|:||.||.:..|.|:|:.|.|:..|..:|:..:|.|||.:|.::..:|.|....||.
 Worm   389 RIREKPIIEQIWRPDPYIVNSKHSYFHYVSFPNIRMRITPEGLVTYTVRVSSVCSCFMSFCLYPH 453

  Fly   186 DSQNCTVEIESYGYTVSDVVMYWKPTPVRGVEDAELPQFTIIGYETND--RKERLATGVYQRLSL 248
            |.|.|.:.|.|..|:...|..:|...|::......||:..|...:|.:  .|.:|...  ..|.:
 Worm   454 DRQECDLRISSIAYSNQYVKFHWHSNPIKFQSKITLPELHITKIKTAECSTKGKLVDA--SCLRI 516

  Fly   249 SFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHEATSARVALGITTVLTMTTISTGVRSSLPRI 313
            .|.|:|:...||.:.|:||.|.:|.:||:.::.:.....|:...||.:||:..:..|.:..  |.
 Worm   517 IFSLERDSARFVIEKYVPSTLAMMFAWVAPYVPYNYEDVRIITPITVLLTLVQMEKGDKEI--RT 579

  Fly   314 SYVKAIDIYLVMCFVFVFAALLEYAAVNYTYWGKRAKKKIKKVKECCPGKIGKSERSETCSTTED 378
            ||:.:||::......|...:|||..||.......||..|             .:||:..
 Worm   580 SYLTSIDVWFAAMKSFTVLSLLESLAVLALIKRSRAMTK-------------NAERAAN------ 625

  Fly   379 IIELQDVRMSPIPSLRRGTYNATLDSIGTETMNLGKFPPSFRITRNYGTGHSQLRRRAQRGISTR 443
                         ...|.|:.|                .::|:.|.|
 Worm   626 -------------EFERCTFEA----------------EAYRLNRLY------------------ 643

  Fly   444 PRMLHALKRGASAIKATIPKIKDVNIIDKYSRMIFPISFLAFNLGYWLF 492
                                    :.:|...|...|:.|:||.:.|.||
 Worm   644 ------------------------HRVDSICRFSSPVVFVAFFVYYVLF 668

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	101/439 (23%)
lgc-43	NP_001023062.1	LGIC_ECD_anion	344..523	CDD:349788	52/195 (27%)
		Cys-loop	444..458	CDD:349788	6/13 (46%)
		LGIC_TM	527..665	CDD:476813	43/229 (19%)
		TM1 helix	529..551	CDD:349851	7/21 (33%)
		TM2 helix	558..577	CDD:349851	5/18 (28%)
		TM3 helix	587..609	CDD:349851	6/21 (29%)
		TM4 helix	645..665	CDD:349851	6/19 (32%)