Protein Alignment Lcch3 and GABRR2

DIOPT Version :10

• Sequence 1: NP_996469.1
• Gene: Lcch3 / 32554
• FlyBaseID: FBgn0010240
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_002034.3
• Gene: GABRR2 / 2570
• HGNCID: 4091
• Length: 465
• Species: Homo sapiens
• Alignment Length: 515
• Identity: 201/515 - (39%)
• Similarity: 283/515 - (54%)
• Gaps: 79/515 - (15%)

  Fly     1 MTCFTRVGVSCGLFFFLLGAQLQLIRCIRKDVLAGRLE--------NVTQTISNILQG------- 50
            |..|||:    .||.|.|...::..:..||. ..|::|        .....::.|.:|
Human     1 MPYFTRL----ILFLFCLMVLVESRKPKRKR-WTGQVEMPKPSHLYKKNLDVTKIRKGKPQQLLR 60

  Fly    51 ---YDIRLRPNFGGEPLHVGMDLTIASFDAISEVNMDYTITMYLNQYWRDERLAFNIFGQYFDDE 112
               :|..:||.|||..:.||:|:.:.|.|:||||:||:|:|:||..||:||||||:
Human    61 VDEHDFSMRPAFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLAFS--------- 116

  Fly   113 NDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKLVRLGGDGAVTYGMRFTTTLACM 177
              ...:..:|..|...:||||||.||.:.|.||.||.|..|.::|:..||.|.|.||.|.|..|.
Human   117 --SASNKSMTFDGRLVKKIWVPDVFFVHSKRSFTHDTTTDNIMLRVFPDGHVLYSMRITVTAMCN 179

  Fly   178 MDLHYYPLDSQNCTVEIESYGYTVSDVVMYWK--PTPVRGVEDAELPQFTIIGYETNDRKERLA- 239
            ||..::|||||.|::|:|||.||..|:::|||  ...::..|...|.||.|..:.|.   .|||
Human   180 MDFSHFPLDSQTCSLELESYAYTDEDLMLYWKNGDESLKTDEKISLSQFLIQKFHTT---SRLAF 241

  Fly   240 ---TGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHEATSARVALGITTVLTMTT 301
               ||.|.||.::|.|:|:|.:|:.|||.|:.|:||||||||||:..|..|||:|||||||||||
Human   242 YSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVSLGITTVLTMTT 306

  Fly   302 ISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVNY-TYWGKRAKKKIKKVKECCPGKIG 365
            |.|||.:|:||:|||||:||||.:.|||||.::|||||||| |...:|.::|:::...|..|.:
Human   307 IITGVNASMPRVSYVKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKERKLREKFPCMCGML- 370

  Fly   366 KSERSETCSTTEDIIELQDVRMSPIPSLRRGTYNATLDSIGTETMNLGKFPPSFRITRNYGTGHS 430
               .|:|                   .:..|:|:.      :|..:|..:|.|..:|..    ..
Human   371 ---HSKT-------------------MMLDGSYSE------SEANSLAGYPRSHILTEE----ER 403

  Fly   431 QLRRRAQRGISTRPRMLHALKRGASAIKATIPKIKDVNIIDKYSRMIFPISFLAFNLGYW 490
            |.:.....|:|.....  |.|:|....:......::.:.||||||:|||.|::.|||.||
Human   404 QDKIVVHLGLSGEANA--ARKKGLLKGQTGFRIFQNTHAIDKYSRLIFPASYIFFNLIYW 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	195/501 (39%)
GABRR2	NP_002034.3	LIC	51..464	CDD:455710	188/460 (41%)
		LGIC_ECD_GABAAR_rho	76..261	CDD:349806	85/198 (43%)
		Cys-loop	178..192	CDD:349806	8/13 (62%)