Protein Alignment Lcch3 and GABRG3

DIOPT Version :9

• Sequence 1: NP_996469.1
• Gene: Lcch3 / 32554
• FlyBaseID: FBgn0010240
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: XP_011519732.1
• Gene: GABRG3 / 2567
• HGNCID: 4088
• Length: 473
• Species: Homo sapiens
• Alignment Length: 496
• Identity: 164/496 - (33%)
• Similarity: 241/496 - (48%)
• Gaps: 88/496 - (17%)

  Fly    29 RKDVLAGRLE--NVTQTISNILQGYDIRLRPNFGGEPLHVGMDLTIASFDAISEVNMDYTITMYL 91
            :|.|||.:.:  :||..::.:|:.||.:|||:.|.:|..:.:|:.:.|...:|.:||:|.|.::.
Human    34 QKWVLAPKSQDTDVTLILNKLLREYDKKLRPDIGIKPTVIDVDIYVNSIGPVSSINMEYQIDIFF 98

  Fly    92 NQYWRDERLAFNIFGQYFDDENDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKLV 156
            .|.|.|.||.||            ....:|||:.:....||:|||.|.|.|.:..|.:|..|:|:
Human    99 AQTWTDSRLRFN------------STMKILTLNSNMVGLIWIPDTIFRNSKTAEAHWITTPNQLL 151

  Fly   157 RLGGDGAVTYGMRFTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYWKPTPVRGVEDA-- 219
            |:..||.:.|.:|.|....|.:.||.:|:|..:|.:...||||...:::..|:...|...:..
Human   152 RIWNDGKILYTLRLTINAECQLQLHNFPMDEHSCPLIFSSYGYPKEEMIYRWRKNSVEAADQKSW 216

  Fly   220 ELPQFTIIGYETNDRKERLATGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHEA 284
            .|.||..:|..........:.|.|..:::.|:|.|.:|||..|||:|.||.|:||||||||..:|
Human   217 RLYQFDFMGLRNTTEIVTTSAGDYVVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDA 281

  Fly   285 TSARVALGITTVLTMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVNYTYWGKRA 349
            |.||.||||||||||||:||..|.||||:|||.|:|:::.:||:||||||:|||.:||
Human   282 TPARTALGITTVLTMTTLSTIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNY------- 339

  Fly   350 KKKIKKVKECCPGKIGKSERSETCSTTEDIIELQDVRMSP------IPSLRRGTYNATLDSIGTE 408
                  ...|        .:..|...|..::.....|..|      .||:|....|.:|..:
Human   340 ------YSSC--------RKPTTTKKTTSLLHPDSSRWIPERISLQAPSVRIALQNYSLLDM--- 387

  Fly   409 TMNLGKFPPSFRITRNYGTGHSQLR--------------------RRAQRGISTRPRMLHALKRG 453
                 :.||:..||.|......:..                    ...:.| |.|...:|.
Human   388 -----RPPPTAMITLNNSVYWQEFEDTCVYECLDGKDCQSFFCCYEECKSG-SWRKGRIHI---- 442

  Fly   454 ASAIKATIPKIKDVNIIDKYSRMIFPISFLAFNLGYWLFYI 494
                        |:..:|.|||:.||.|||.|||.||:.|:
Human   443 ------------DILELDSYSRVFFPTSFLLFNLVYWVGYL 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	163/493 (33%)
		Neur_chan_LBD	47..256	CDD:280998	64/210 (30%)
		Neur_chan_memb	263..490	CDD:280999	87/252 (35%)
GABRG3	XP_011519732.1	Neur_chan_LBD	48..253	CDD:280998	65/216 (30%)
		LIC	50..470	CDD:273305	157/477 (33%)
		Neur_chan_memb	260..467	CDD:280999	87/252 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810