Protein Alignment Lcch3 and GABRG1

DIOPT Version :9

• Sequence 1: NP_996469.1
• Gene: Lcch3 / 32554
• FlyBaseID: FBgn0010240
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_775807.2
• Gene: GABRG1 / 2565
• HGNCID: 4086
• Length: 465
• Species: Homo sapiens
• Alignment Length: 512
• Identity: 176/512 - (34%)
• Similarity: 250/512 - (48%)
• Gaps: 101/512 - (19%)

  Fly    13 LFFFLLGAQLQLIRCIRKD--------------VLAGRLE--NVTQTISNILQGYDIRLRPNFGG 61
            |.|.||  .|.|..|:.|.              |||.::.  ::||.::::|||||.:|||:.|.
Human    23 LVFLLL--TLHLGNCVDKADDEDDEDLTVNKTWVLAPKIHEGDITQILNSLLQGYDNKLRPDIGV 85

  Fly    62 EPLHVGMDLTIASFDAISEVNMDYTITMYLNQYWRDERLAFNIFGQYFDDENDDGISDVLTLSGD 126
            .|..:..|:.:.|...:..:||:|||.:...|.|.|.||.||            ....||.|:.:
Human    86 RPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWFDSRLKFN------------STMKVLMLNSN 138

  Fly   127 FAEKIWVPDTFFANDKNSFLHDVTERNKLVRLGGDGAVTYGMRFTTTLACMMDLHYYPLDSQNCT 191
            ...|||:|||||.|.:.|..|.:|..|:|:|:..||.|.|.:|.|....|.:.||.:|:|..:|.
Human   139 MVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLYTLRLTINAECYLQLHNFPMDEHSCP 203

  Fly   192 VEIESYGYTVSDVVMYWKPTPVRGVEDAE---LPQFTIIGYETNDRKERLATGVYQRLSLSFKLQ 253
            :|..||||..:::...||...|. |.|.:   |.||..:|...:.......:|.|..:::.|.|.
Human   204 LEFSSYGYPKNEIEYKWKKPSVE-VADPKYWRLYQFAFVGLRNSTEITHTISGDYVIMTIFFDLS 267

  Fly   254 RNIGYFVFQTYLPSILIVMLSWVSFWINHEATSARVALGITTVLTMTTISTGVRSSLPRISYVKA 318
            |.:|||..|||:|.||.|:|||||||||.:|..||.:|||||||||||:||..|.|||::|||.|
Human   268 RRMGYFTIQTYIPCILTVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTA 332

  Fly   319 IDIYLVMCFVFVFAALLEYAAVNY---TYWGKRAKK--KIKKVKECCPGKIGKSERSETCSTTED 378
            :|:::.:||:||||||:||..::|   ...||.|.|  |:|......||          ......
Human   333 MDLFVSVCFIFVFAALMEYGTLHYFTSNQKGKTATKDRKLKNKASMTPG----------LHPGST 387

  Fly   379 IIELQDVRMSPIPSLRRGTYNATLDSIGTETMNLGKFPPSFRI------TRNYGTGHSQLRRRAQ 437
            :|.:.::   .:|.         .|..|.:.:. ||...||..      |.::..|...:|
Human   388 LIPMNNI---SVPQ---------EDDYGYQCLE-GKDCASFFCCFEDCRTGSWREGRIHIR---- 435

  Fly   438 RGISTRPRMLHALKRGASAIKATIPKIKDVNIIDKYSRMIFPISFLAFNLGYWLFYI 494
                                   |.|      ||.|||:.||.:|..|||.||:.|:
Human   436 -----------------------IAK------IDSYSRIFFPTAFALFNLVYWVGYL 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	174/507 (34%)
		Neur_chan_LBD	47..256	CDD:280998	73/211 (35%)
		Neur_chan_memb	263..490	CDD:280999	83/237 (35%)
GABRG1	NP_775807.2	LIC	66..462	CDD:273305	163/464 (35%)
		LGIC_ECD_GABAAR_G	88..269	CDD:349801	62/193 (32%)
		Cys-loop	188..202	CDD:349801	5/13 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810