Protein Alignment Lcch3 and GABRE

DIOPT Version :9

• Sequence 1: NP_996469.1
• Gene: Lcch3 / 32554
• FlyBaseID: FBgn0010240
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_004952.2
• Gene: GABRE / 2564
• HGNCID: 4085
• Length: 506
• Species: Homo sapiens
• Alignment Length: 478
• Identity: 145/478 - (30%)
• Similarity: 236/478 - (49%)
• Gaps: 63/478 - (13%)

  Fly    35 GRLENVTQTISNILQGYDIRLRPNFGGEPLHVGMDLTIASFDAISEVNMDYTITMYLNQYWRDER 99
            |:|...::.::.||..||.:|||..|.:|..|.:::::.|...:|.::|:|||.:..:|.|.|||
Human    66 GKLPEASRILNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDIIFSQTWYDER 130

  Fly   100 LAFNIFGQYFDDENDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKLVRLGGDGAV 164
            |.:|   ..|:.         |.|:|:...::|:|||||.|.|.:..|::|..|::||:..||.|
Human   131 LCYN---DTFES---------LVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKDGKV 183

  Fly   165 TYGMRFTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYWK--PTPVRGVEDAELPQFTII 227
            .|.:|.|....|.:.:..:|:||.:|.:...|:.|..::::..|:  ...:......:|.||...
Human   184 LYTIRMTIDAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKWENFKLEINEKNSWKLFQFDFT 248

  Fly   228 GYETNDRKERLAT--GVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHEATSARVA 290
            |  .:::.|.:.|  |.:..:::.|.:.|..||..||.|:||.:..|||||||||..|:..||.:
Human   249 G--VSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFWIKTESAPARTS 311

  Fly   291 LGITTVLTMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVNYTYWGK---RAKKK 352
            ||||:||||||:.|..|.:.||:||:.|:|.|:.:||||.|.||||:|.:|:..:.:   .|..|
Human   312 LGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAVLNFLIYNQTKAHASPK 376

  Fly   353 IKKVKECCPGKIGKSERSETCSTTEDIIELQDVRMSPIPSLRRGTYNATLDSIGTETMNLGKFPP 417
            ::..:...........||..|:                    |....|.:..|.|...:.|:..|
Human   377 LRHPRINSRAHARTRARSRACA--------------------RQHQEAFVCQIVTTEGSDGEERP 421

  Fly   418 SFRITRNYGTGHSQLRRRAQRGISTRPRMLHALKRGASAIKATIPKIKD--------------VN 468
            |....:....|..:    ..|.:.::.......||    .|.....:.|              |.
Human   422 SCSAQQPPSPGSPE----GPRSLCSKLACCEWCKR----FKKYFCMVPDCEGSTWQQGRLCIHVY 478

  Fly   469 IIDKYSRMIFPISFLAFNLGYWL 491
            .:|.|||::||::|..||:.|||
Human   479 RLDNYSRVVFPVTFFFFNVLYWL 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	145/478 (30%)
		Neur_chan_LBD	47..256	CDD:280998	63/212 (30%)
		Neur_chan_memb	263..490	CDD:280999	73/243 (30%)
GABRE	NP_004952.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	23..66		145/478 (30%)
		Neur_chan_LBD	71..276	CDD:280998	62/218 (28%)
		Neur_chan_memb	285..>408	CDD:280999	52/142 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	413..438		4/28 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810