DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lcch3 and GABRD

DIOPT Version :9

Sequence 1:	NP_996469.1	Gene:	Lcch3 / 32554	FlyBaseID:	FBgn0010240	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	XP_016856425.1	Gene:	GABRD / 2563	HGNCID:	4084	Length:	687	Species:	Homo sapiens

Alignment Length:	492	Identity:	183/492 - (37%)
Similarity:	266/492 - (54%)	Gaps:	82/492 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 CIRK------DVLAGRLE-NVTQTISNILQGYDIRLRPNFGGEPLHVGMDLTIASFDAISEVNMD 84
            ||.:      |.:...|| :....:..::.||....||..||.|::|.:.|.:||.|.|||.||:
Human   255 CIPRAMNDIGDYVGSNLEISWLPNLDGLIAGYARNFRPGIGGPPVNVALALEVASIDHISEANME 319

  Fly    85 YTITMYLNQYWRDERLAFNIFGQYFDDENDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDV 149
            ||:|::|:|.|||.||::|            ..::.|.|...|.:|:|:||||..|.|:::.|||
Human   320 YTMTVFLHQSWRDSRLSYN------------HTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDV 372

  Fly   150 TERNKLVRLGGDGAVTYGMRFTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYWKPTP-- 212
            |..|||:||..||.:.|.:|.|:|:||.|||..||:|.|.|.:::|||||:..|:|.||..:.
Human   373 TVENKLIRLQPDGVILYSIRITSTVACDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSESQEH 437

  Fly   213 VRGVEDAELPQFTIIGYE-TNDRKERLATGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWV 276
            :.|::..:|.||||..|. |.:.....:.|.:.||||.|.|:||.|.::.|:|:||:|:|.:|||
Human   438 IHGLDKLQLAQFTITSYRFTTELMNFKSAGQFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWV 502

  Fly   277 SFWINHEATSARVALGITTVLTMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVN 341
            ||||:..|..|||:|||||||||||:....||||||.|.:||:|:|..:|:|||||||:|||..:
Human   503 SFWISQAAVPARVSLGITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAH 567

  Fly   342 YTYWGKRAKKKIKKVKECCPGKIGKSERSE-------------TCSTTEDIIELQDVRMSPIPSL 393
            :.  ....||:..|||...|       |:|             ....|:::...:  |...:|..
Human   568 FN--ADYRKKQKAKVKVSRP-------RAEMDVRNAIVLFSLSAAGVTQELAISR--RQRRVPGN 621

  Fly   394 RRGTYNATLDSIGTETMNLGKFPPSFRITRNYGTGHSQLRRRAQRGISTRPRMLHALKRGASAIK 458
            ..|:|.    |:|.|                  ||.::....|:.|             |...|:
Human   622 LMGSYR----SVGVE------------------TGETKKEGAARSG-------------GQGGIR 651

  Fly   459 ATIPKIKDVNIIDKYSRMIFPISFLAFNLGYWLFYIL 495
            |.:..| |.:.||.|:|.:||.:|.|.|:.||..|.:
Human   652 ARLRPI-DADTIDIYARAVFPAAFAAVNVIYWAAYAM 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	182/488 (37%)
		Neur_chan_LBD	47..256	CDD:280998	89/211 (42%)
		Neur_chan_memb	263..490	CDD:280999	83/239 (35%)
GABRD	XP_016856425.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D226476at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920