Protein Alignment Lcch3 and GABRD

DIOPT Version :10

• Sequence 1: NP_996469.1
• Gene: Lcch3 / 32554
• FlyBaseID: FBgn0010240
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: XP_016856425.1
• Gene: GABRD / 2563
• HGNCID: 4084
• Length: 687
• Species: Homo sapiens
• Alignment Length: 492
• Identity: 183/492 - (37%)
• Similarity: 266/492 - (54%)
• Gaps: 82/492 - (16%)

  Fly    27 CIRK------DVLAGRLE-NVTQTISNILQGYDIRLRPNFGGEPLHVGMDLTIASFDAISEVNMD 84
            ||.:      |.:...|| :....:..::.||....||..||.|::|.:.|.:||.|.|||.||:
Human   255 CIPRAMNDIGDYVGSNLEISWLPNLDGLIAGYARNFRPGIGGPPVNVALALEVASIDHISEANME 319

  Fly    85 YTITMYLNQYWRDERLAFNIFGQYFDDENDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDV 149
            ||:|::|:|.|||.||::|            ..::.|.|...|.:|:|:||||..|.|:::.|||
Human   320 YTMTVFLHQSWRDSRLSYN------------HTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDV 372

  Fly   150 TERNKLVRLGGDGAVTYGMRFTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYWKPTP-- 212
            |..|||:||..||.:.|.:|.|:|:||.|||..||:|.|.|.:::|||||:..|:|.||..:.
Human   373 TVENKLIRLQPDGVILYSIRITSTVACDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSESQEH 437

  Fly   213 VRGVEDAELPQFTIIGYE-TNDRKERLATGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWV 276
            :.|::..:|.||||..|. |.:.....:.|.:.||||.|.|:||.|.::.|:|:||:|:|.:|||
Human   438 IHGLDKLQLAQFTITSYRFTTELMNFKSAGQFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWV 502

  Fly   277 SFWINHEATSARVALGITTVLTMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVN 341
            ||||:..|..|||:|||||||||||:....||||||.|.:||:|:|..:|:|||||||:|||..:
Human   503 SFWISQAAVPARVSLGITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAH 567

  Fly   342 YTYWGKRAKKKIKKVKECCPGKIGKSERSE-------------TCSTTEDIIELQDVRMSPIPSL 393
            :.  ....||:..|||...|       |:|             ....|:::...:  |...:|..
Human   568 FN--ADYRKKQKAKVKVSRP-------RAEMDVRNAIVLFSLSAAGVTQELAISR--RQRRVPGN 621

  Fly   394 RRGTYNATLDSIGTETMNLGKFPPSFRITRNYGTGHSQLRRRAQRGISTRPRMLHALKRGASAIK 458
            ..|:|.    |:|.|                  ||.::....|:.|             |...|:
Human   622 LMGSYR----SVGVE------------------TGETKKEGAARSG-------------GQGGIR 651

  Fly   459 ATIPKIKDVNIIDKYSRMIFPISFLAFNLGYWLFYIL 495
            |.:..| |.:.||.|:|.:||.:|.|.|:.||..|.:
Human   652 ARLRPI-DADTIDIYARAVFPAAFAAVNVIYWAAYAM 687

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	182/488 (37%)
GABRD	XP_016856425.1	LGIC_ECD_GABAAR_delta	298..481	CDD:349802	82/194 (42%)
		Cys-loop	399..413	CDD:349802	8/13 (62%)
		LGIC_TM_GABAAR_delta	484..>578	CDD:349857	52/95 (55%)
		TM1 helix	484..507	CDD:349857	12/22 (55%)
		TM2 helix	511..535	CDD:349857	15/23 (65%)
		TM3 helix	543..569	CDD:349857	15/25 (60%)