DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lcch3 and GABRB2

DIOPT Version :9

Sequence 1:	NP_996469.1	Gene:	Lcch3 / 32554	FlyBaseID:	FBgn0010240	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001358656.1	Gene:	GABRB2 / 2561	HGNCID:	4082	Length:	512	Species:	Homo sapiens

Alignment Length:	501	Identity:	235/501 - (46%)
Similarity:	311/501 - (62%)	Gaps:	71/501 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 VTQTISNILQGYDIRLRPNFGGEPLHVGMDLTIASFDAISEVNMDYTITMYLNQYWRDERLAFNI 104
            |.:|:..:|:||||||||:|||.|:.|||::.|||.|.:||||||||:|||..|.|||:||::|:
Human    36 VKETVDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNV 100

  Fly   105 FGQYFDDENDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKLVRLGGDGAVTYGMR 169
                        |...|||....|:::|||||:|.|||.||:|.||.:|:::||..||.|.||:|
Human   101 ------------IPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLR 153

  Fly   170 FTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYWK--PTPVRGVEDAELPQFTIIGYETN 232
            .|||.||||||..||||.||||:||||||||..|:..||:  ...|.||...|||||:|:.|:..
Human   154 ITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLI 218

  Fly   233 DRKERLATGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHEATSARVALGITTVL 297
            .:|...:||.|.||||||||:||||||:.|||:|||||.:|||||||||::|::|||||||||||
Human   219 TKKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVL 283

  Fly   298 TMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVNYTYWGK---RAKKKIKKVKEC 359
            |||||:|.:|.:||:|.||||||:||:.||||||.||||||.|||.::|:   |.||..:|
Human   284 TMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEK---- 344

  Fly   360 CPGKIGKSERSETCSTTEDIIELQDVRMSPI-------------PSLRRGTYN------------ 399
                 ..|..:|......:.|..:|::.:..             |:.|...|:
Human   345 -----AASANNEKMRLDVNKIFYKDIKQNGTQYRSLWDPTGNLSPTRRTTNYDFSLYTMDPHENI 404

  Fly   400 --ATLD-----SIGTETMNLGKFPPSFRIT--------RNYG-TGHSQLRRRAQRGISTRPRMLH 448
              :||:     :.....|.||. |.|..:.        |..| ..||..|...:|.::.:.   .
Human   405 LLSTLEIKNEMATSEAVMGLGD-PRSTMLAYDASSIQYRKAGLPRHSFGRNALERHVAQKK---S 465

  Fly   449 ALKRGASAIKATIPKIKDVNIIDKYSRMIFPISFLAFNLGYWLFYI 494
            .|:|.||.:|.|||.:.|||.||::||:.||:.|..||:.|||:|:
Human   466 RLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYV 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	234/498 (47%)
		Neur_chan_LBD	47..256	CDD:280998	117/210 (56%)
		Neur_chan_memb	263..490	CDD:280999	106/270 (39%)
GABRB2	NP_001358656.1	LIC	9..510	CDD:273305	234/498 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	248	1.000	Domainoid score	I2142
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	433	1.000	Inparanoid score	I1712
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D226476at33208
OrthoFinder	1	1.000	-	-		FOG0001081
OrthoInspector	1	1.000	-	-		otm40836
orthoMCL	1	0.900	-	-		OOG6_101786
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2537
SonicParanoid	1	1.000	-	-		X650
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.960