Protein Alignment Lcch3 and GABRA6

DIOPT Version :10

• Sequence 1: NP_996469.1
• Gene: Lcch3 / 32554
• FlyBaseID: FBgn0010240
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_000802.2
• Gene: GABRA6 / 2559
• HGNCID: 4080
• Length: 453
• Species: Homo sapiens
• Alignment Length: 461
• Identity: 161/461 - (34%)
• Similarity: 244/461 - (52%)
• Gaps: 53/461 - (11%)

  Fly    38 ENVTQTISNILQGYDIRLRPNFGGEPLHVGMDLTIASFDAISEVNMDYTITMYLNQYWRDERLAF 102
            |||::.:.|:|:|||.||||.|||....|..|:.:.||..:|:|.|:||:.::..|.|.||||.|
Human    30 ENVSRILDNLLEGYDNRLRPGFGGAVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKF 94

  Fly   103 NIFGQYFDDENDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKLVRLGGDGAVTYG 167
            .            |.:::|:|:.....|||.|||||.|.|.|..|::|..|||.|:..:|.:.|.
Human    95 G------------GPTEILSLNNLMVSKIWTPDTFFRNGKKSIAHNMTTPNKLFRIMQNGTILYT 147

  Fly   168 MRFTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYWKPTPVRGV----EDAELPQFTIIG 228
            ||.|....|.|.|..:|:|...|.::..||.|..|:::..||..|:..|    |.:.|.|:.:||
Human   148 MRLTINADCPMRLVNFPMDGHACPLKFGSYAYPKSEIIYTWKKGPLYSVEVPEESSSLLQYDLIG 212

  Fly   229 YETNDRKERLATGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHEATSARVALGI 293
            ...:....:..||.|..:::.|.|||.:|||:.|.|.|.|:.|:||.||||||.|:..||...||
Human   213 QTVSSETIKSNTGEYVIMTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGI 277

  Fly   294 TTVLTMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVNYTYWGKRAKKKIKKVKE 358
            ||||||||:|...|.|||::||..|:|.::.:||.|||:||:|:||||| :...:.:|..:|.:.
Human   278 TTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNY-FTNLQTQKAKRKAQF 341

  Fly   359 CCPGKIGKSERSETCSTTEDIIELQDVRMSPIPSLRRGTYNATLDSIGTETMNLGKFPPSFRITR 423
            ..|..:..|:.:|....  :|:...|.:.    .|::...:.:|..:.:...|
Human   342 AAPPTVTISKATEPLEA--EIVLHPDSKY----HLKKRITSLSLPIVSSSEAN------------ 388

  Fly   424 NYGTGHSQLRRRAQRGISTRPRMLHALKRGASAIKATIPKIKDVNIIDKYSRMIFPISFLAFNLG 488
                           .:.||..:|.:.......:.   |.....:.||:|||::||::|..|||.
Human   389 ---------------KVLTRAPILQSTPVTPPPLS---PAFGGTSKIDQYSRILFPVAFAGFNLV 435

  Fly   489 YWLFYI 494
            ||:.|:
Human   436 YWVVYL 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	160/458 (35%)
GABRA6	NP_000802.2	LIC	5..440	CDD:455710	160/458 (35%)
		LGIC_ECD_GABAAR_A6	42..239	CDD:349840	76/208 (37%)
		Cys-loop	156..170	CDD:349840	5/13 (38%)