Protein Alignment Lcch3 and GABRA6

DIOPT Version :9

• Sequence 1: NP_996469.1
• Gene: Lcch3 / 32554
• FlyBaseID: FBgn0010240
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_000802.2
• Gene: GABRA6 / 2559
• HGNCID: 4080
• Length: 453
• Species: Homo sapiens
• Alignment Length: 461
• Identity: 161/461 - (34%)
• Similarity: 244/461 - (52%)
• Gaps: 53/461 - (11%)

  Fly    38 ENVTQTISNILQGYDIRLRPNFGGEPLHVGMDLTIASFDAISEVNMDYTITMYLNQYWRDERLAF 102
            |||::.:.|:|:|||.||||.|||....|..|:.:.||..:|:|.|:||:.::..|.|.||||.|
Human    30 ENVSRILDNLLEGYDNRLRPGFGGAVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKF 94

  Fly   103 NIFGQYFDDENDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKLVRLGGDGAVTYG 167
            .            |.:::|:|:.....|||.|||||.|.|.|..|::|..|||.|:..:|.:.|.
Human    95 G------------GPTEILSLNNLMVSKIWTPDTFFRNGKKSIAHNMTTPNKLFRIMQNGTILYT 147

  Fly   168 MRFTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYWKPTPVRGV----EDAELPQFTIIG 228
            ||.|....|.|.|..:|:|...|.::..||.|..|:::..||..|:..|    |.:.|.|:.:||
Human   148 MRLTINADCPMRLVNFPMDGHACPLKFGSYAYPKSEIIYTWKKGPLYSVEVPEESSSLLQYDLIG 212

  Fly   229 YETNDRKERLATGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHEATSARVALGI 293
            ...:....:..||.|..:::.|.|||.:|||:.|.|.|.|:.|:||.||||||.|:..||...||
Human   213 QTVSSETIKSNTGEYVIMTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGI 277

  Fly   294 TTVLTMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVNYTYWGKRAKKKIKKVKE 358
            ||||||||:|...|.|||::||..|:|.::.:||.|||:||:|:||||| :...:.:|..:|.:.
Human   278 TTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNY-FTNLQTQKAKRKAQF 341

  Fly   359 CCPGKIGKSERSETCSTTEDIIELQDVRMSPIPSLRRGTYNATLDSIGTETMNLGKFPPSFRITR 423
            ..|..:..|:.:|....  :|:...|.:.    .|::...:.:|..:.:...|
Human   342 AAPPTVTISKATEPLEA--EIVLHPDSKY----HLKKRITSLSLPIVSSSEAN------------ 388

  Fly   424 NYGTGHSQLRRRAQRGISTRPRMLHALKRGASAIKATIPKIKDVNIIDKYSRMIFPISFLAFNLG 488
                           .:.||..:|.:.......:.   |.....:.||:|||::||::|..|||.
Human   389 ---------------KVLTRAPILQSTPVTPPPLS---PAFGGTSKIDQYSRILFPVAFAGFNLV 435

  Fly   489 YWLFYI 494
            ||:.|:
Human   436 YWVVYL 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	160/458 (35%)
		Neur_chan_LBD	47..256	CDD:280998	78/212 (37%)
		Neur_chan_memb	263..490	CDD:280999	72/226 (32%)
GABRA6	NP_000802.2	Neur_chan_LBD	5..440	CDD:332142	160/458 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810