Protein Alignment Lcch3 and GABRA5

DIOPT Version :9

• Sequence 1: NP_996469.1
• Gene: Lcch3 / 32554
• FlyBaseID: FBgn0010240
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_000801.1
• Gene: GABRA5 / 2558
• HGNCID: 4079
• Length: 462
• Species: Homo sapiens
• Alignment Length: 482
• Identity: 168/482 - (34%)
• Similarity: 237/482 - (49%)
• Gaps: 88/482 - (18%)

  Fly    30 KDVLAGRLENVTQTISNILQGYDIRLRPNFGGEPLHVGMDLTIASFDAISEVNMDYTITMYLNQY 94
            ||.....:...|:.:..:|.|||.||||..|.....|..|:.:.||..:|:..|:|||.::..|.
Human    39 KDETNDNITIFTRILDGLLDGYDNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQS 103

  Fly    95 WRDERLAFNIFGQYFDDENDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKLVRLG 159
            |:||||.|.            |....|.|:...|.|||.|||||.|.|.|..|::|..|||:||.
Human   104 WKDERLRFK------------GPMQRLPLNNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLE 156

  Fly   160 GDGAVTYGMRFTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYWKPTPVRGVEDAE---- 220
            .||.:.|.||.|.:..|.|.|..:|:|:..|.::..||.|..|:||..|.....:.|..||
Human   157 DDGTLLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSR 221

  Fly   221 LPQFTIIGYETNDRKERLATGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHEAT 285
            |.|:.::|..........:||.|..::..|.|:|.|||||.|||||.|:.|:||.||||:|.|:.
Human   222 LNQYHLMGQTVGTENISTSTGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESV 286

  Fly   286 SARVALGITTVLTMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVNY------TY 344
            .||...|:||||||||:|...|:|||:::|..|:|.::.:|:.|||:||:|:|.|||      .:
Human   287 PARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAW 351

  Fly   345 WGKRAKK--KIKKVKECCPGKIGKSERSETCSTTEDIIELQDVRMSPIPSLRR-----GTYNATL 402
            .||:|.:  ||||.:|..   :.||..:.|..           :||..|::.:     ||.|.|
Human   352 DGKKALEAAKIKKKREVI---LNKSTNAFTTG-----------KMSHPPNIPKEQTPAGTSNTT- 401

  Fly   403 DSIGTETMNLGKFPPSFRITRNYGTGHSQLRRRAQRGISTRPRMLHALKRGASAIKATIPKIKDV 467
                                                .:|.:|.     :...|..|.|   ...:
Human   402 ------------------------------------SVSVKPS-----EEKTSESKKT---YNSI 422

  Fly   468 NIIDKYSRMIFPISFLAFNLGYWLFYI 494
            :.|||.||::||:.|..|||.||..|:
Human   423 SKIDKMSRIVFPVLFGTFNLVYWATYL 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	167/479 (35%)
		Neur_chan_LBD	47..256	CDD:280998	78/212 (37%)
		Neur_chan_memb	263..490	CDD:280999	78/239 (33%)
GABRA5	NP_000801.1	LGIC_ECD_GABAAR_A5	58..256	CDD:349839	76/209 (36%)
		LGIC_TM_GABAAR_alpha	259..445	CDD:349854	82/244 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	377..412		10/87 (11%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810