DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lcch3 and GABRA3

DIOPT Version :9

Sequence 1:	NP_996469.1	Gene:	Lcch3 / 32554	FlyBaseID:	FBgn0010240	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_000799.1	Gene:	GABRA3 / 2556	HGNCID:	4077	Length:	492	Species:	Homo sapiens

Alignment Length:	482	Identity:	172/482 - (35%)
Similarity:	248/482 - (51%)	Gaps:	75/482 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 DVLAGRLENV---TQTISNILQGYDIRLRPNFGGEPLHVGMDLTIASFDAISEVNMDYTITMYLN 92
            |:.....:|:   |:.:..:|.|||.||||..|.....|..|:.:.||..:|:.:|:|||.::..
Human    55 DIPDDSTDNITIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFR 119

  Fly    93 QYWRDERLAFNIFGQYFDDENDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKLVR 157
            |.|.||||.|            ||...:|.|:...|.|||.|||||.|.|.|..|::|..|||:|
Human   120 QTWHDERLKF------------DGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLR 172

  Fly   158 LGGDGAVTYGMRFTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYWKPTPVRGVEDAE-- 220
            |..:|.:.|.||.|....|.|.|..:|:|...|.::..||.||.::||..|.....:.||.|:
Human   173 LVDNGTLLYTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTTAEVVYSWTLGKNKSVEVAQDG 237

  Fly   221 --LPQFTIIGYETNDRKERLATGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHE 283
              |.|:.::|:.......|.:||.|..::..|.|:|.|||||.|||||.|:.|:||.||||:|.|
Human   238 SRLNQYDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRE 302

  Fly   284 ATSARVALGITTVLTMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVNY---TYW 345
            :..||...|:||||||||:|...|:|||:::|..|:|.::.:|:.|||:||:|:|.|||   ..|
Human   303 SVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRSW 367

  Fly   346 GKRAKK-----KIKKVKECCPGKIGKSERSETCSTTEDIIELQDVRMSPIPSLRRGTYNATLDSI 405
            ....||     ::||.....|.|        ..|||.:|:               ||
Human   368 AWEGKKVPEALEMKKKTPAAPAK--------KTSTTFNIV---------------GT-------- 401

  Fly   406 GTETMNLGKFPPSFRITRNYGTGHSQLRRRAQRGISTRPRMLHALKRGASAIKATIPKIK---DV 467
             |..:||.|           .|..|.:.:.|....|:.|.::.:.|  |:.::.:..:.|   .|
Human   402 -TYPINLAK-----------DTEFSTISKGAAPSASSTPTIIASPK--ATYVQDSPTETKTYNSV 452

  Fly   468 NIIDKYSRMIFPISFLAFNLGYWLFYI 494
            :.:||.||:|||:.|..|||.||..|:
Human   453 SKVDKISRIIFPVLFAIFNLVYWATYV 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	171/479 (36%)
		Neur_chan_LBD	47..256	CDD:280998	79/212 (37%)
		Neur_chan_memb	263..490	CDD:280999	81/237 (34%)
GABRA3	NP_000799.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..54
		LIC	69..478	CDD:273305	168/465 (36%)
		LGIC_ECD_GABAAR_A3	75..274	CDD:349837	78/210 (37%)
		Cys-loop	191..205	CDD:349837	5/13 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810