DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lcch3 and Gabrb2

DIOPT Version :9

Sequence 1:	NP_996469.1	Gene:	Lcch3 / 32554	FlyBaseID:	FBgn0010240	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	XP_008765857.1	Gene:	Gabrb2 / 25451	RGDID:	2650	Length:	506	Species:	Rattus norvegicus

Alignment Length:	492	Identity:	238/492 - (48%)
Similarity:	311/492 - (63%)	Gaps:	59/492 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 VTQTISNILQGYDIRLRPNFGGEPLHVGMDLTIASFDAISEVNMDYTITMYLNQYWRDERLAFNI 104
            |.:|:..:|:||||||||:|||.|:.|||::.|||.|.:||||||||:|||..|.|||:||::|:
  Rat    36 VKETVDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNV 100

  Fly   105 FGQYFDDENDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKLVRLGGDGAVTYGMR 169
                        |...|||....|:::|||||:|.|||.||:|.||.:|:::||..||.|.||:|
  Rat   101 ------------IPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLR 153

  Fly   170 FTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYWK--PTPVRGVEDAELPQFTIIGYETN 232
            .|||.||||||..||||.||||:||||||||..|:..||:  ...|.||...|||||:|:.|:..
  Rat   154 ITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLI 218

  Fly   233 DRKERLATGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHEATSARVALGITTVL 297
            .:|...:||.|.||||||||:||||||:.|||:|||||.:|||||||||::|::|||||||||||
  Rat   219 TKKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVL 283

  Fly   298 TMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVNYTYWGK---RAKKKIKKVKEC 359
            |||||:|.:|.:||:|.||||||:||:.||||||.||||||.|||.::|:   |.||..:|....
  Rat   284 TMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAANA 348

  Fly   360 CPGKIG-----------KSERSE-------TCSTTEDIIELQDVRMSPIPSLRRGTYN-----AT 401
            ...|:.           |..|::       |..||.....|  ..|.|..::...|..     ||
  Rat   349 NNEKMRLDVNKIFYKDIKQNRTQYQSLWDPTRWTTYYHFSL--YMMDPHENILLSTLEIKNEMAT 411

  Fly   402 LDSIGTETMNLGKFPPSFRIT--------RNYG-TGHSQLRRRAQRGISTRPRMLHALKRGASAI 457
            .:::    |.||. |.|..:.        |..| ..||..|...:|.::.:.   ..|:|.||.:
  Rat   412 SEAV----MGLGD-PRSTMLAYDASSIQYRKAGLPRHSFGRNALERHVAQKK---SRLRRRASQL 468

  Fly   458 KATIPKIKDVNIIDKYSRMIFPISFLAFNLGYWLFYI 494
            |.|||.:.|||.||::||:.||:.|..||:.|||:|:
  Rat   469 KITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYV 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	237/489 (48%)
		Neur_chan_LBD	47..256	CDD:280998	117/210 (56%)
		Neur_chan_memb	263..490	CDD:280999	109/261 (42%)
Gabrb2	XP_008765857.1	LIC	9..504	CDD:273305	237/489 (48%)
		Neur_chan_LBD	40..242	CDD:280998	117/213 (55%)
		Neur_chan_memb	249..501	CDD:280999	109/261 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	248	1.000	Domainoid score	I2068
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	435	1.000	Inparanoid score	I1642
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D226476at33208
OrthoFinder	1	1.000	-	-		FOG0001081
OrthoInspector	1	1.000	-	-		otm44980
orthoMCL	1	0.900	-	-		OOG6_101786
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X650
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.830