DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lcch3 and Gabrb3

DIOPT Version :9

Sequence 1:	NP_996469.1	Gene:	Lcch3 / 32554	FlyBaseID:	FBgn0010240	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_058761.2	Gene:	Gabrb3 / 24922	RGDID:	2651	Length:	473	Species:	Rattus norvegicus

Alignment Length:	494	Identity:	240/494 - (48%)
Similarity:	317/494 - (64%)	Gaps:	31/494 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GVSCGLFFFLLGAQ-LQLIRCIRKDVL-AGRLENVTQTISNILQGYDIRLRPNFGGEPLHVGMDL 70
            |.:.|..|.:..|. |..:.|..:.|. .|.:..|.:|:..:|:||||||||:|||.|:.|||::
  Rat     3 GFAGGRLFGIFSAPVLVAVVCCAQSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNI 67

  Fly    71 TIASFDAISEVNMDYTITMYLNQYWRDERLAFNIFGQYFDDENDDGISDVLTLSGDFAEKIWVPD 135
            .|||.|.:||||||||:|||..|||||:|||::            ||...|||....|:::||||
  Rat    68 DIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYS------------GIPLNLTLDNRVADQLWVPD 120

  Fly   136 TFFANDKNSFLHDVTERNKLVRLGGDGAVTYGMRFTTTLACMMDLHYYPLDSQNCTVEIESYGYT 200
            |:|.|||.||:|.||.:|:::||..||.|.||:|.|||.||||||..||||.||||:||||||||
  Rat   121 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYT 185

  Fly   201 VSDVVMYWK--PTPVRGVEDAELPQFTIIGYETNDRKERLATGVYQRLSLSFKLQRNIGYFVFQT 263
            ..|:..||:  ...|.|||..|||||:|:.:....|....|||.|.||||||:|:||||||:.||
  Rat   186 TDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQT 250

  Fly   264 YLPSILIVMLSWVSFWINHEATSARVALGITTVLTMTTISTGVRSSLPRISYVKAIDIYLVMCFV 328
            |:|||||.:|||||||||::|::||||||||||||||||:|.:|.:||:|.||||||:||:.|||
  Rat   251 YMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFV 315

  Fly   329 FVFAALLEYAAVNYTYWGKRAKKKIKKVKECCPGKIGKSERSETCSTTEDIIELQDVRMSPIPSL 393
            |||.||||||.|||.::| |..::.||:.|    |..|::...:.|....:....::.::|:..
  Rat   316 FVFLALLEYAFVNYIFFG-RGPQRQKKLAE----KTAKAKNDRSKSEINRVDAHGNILLAPMDV- 374

  Fly   394 RRGTYNATLDSIGTETMNLGKFPPS---FRITRNYGTGHSQLRRRAQRGISTRPRMLHALKRGAS 455
             ....|....|:|....:...|..|   :|.......||.  |....|.|   |.....|:|.:|
  Rat   375 -HNEMNEVAGSVGDTRNSAISFDNSGIQYRKQSMPKEGHG--RYMGDRSI---PHKKTHLRRRSS 433

  Fly   456 AIKATIPKIKDVNIIDKYSRMIFPISFLAFNLGYWLFYI 494
            .:|..||.:.|||.||::||::||.:|..|||.|||:|:
  Rat   434 QLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYV 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	237/484 (49%)
		Neur_chan_LBD	47..256	CDD:280998	119/210 (57%)
		Neur_chan_memb	263..490	CDD:280999	101/229 (44%)
Gabrb3	NP_058761.2	LIC	10..471	CDD:273305	237/484 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	248	1.000	Domainoid score	I2068
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H633
Inparanoid	1	1.050	435	1.000	Inparanoid score	I1642
OMA	1	1.010	-	-		QHG47165
OrthoDB	1	1.010	-	-		D226476at33208
OrthoFinder	1	1.000	-	-		FOG0001081
OrthoInspector	1	1.000	-	-		otm44980
orthoMCL	1	0.900	-	-		OOG6_101786
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X650
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.980