DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lcch3 and Gabrp

DIOPT Version :9

Sequence 1:	NP_996469.1	Gene:	Lcch3 / 32554	FlyBaseID:	FBgn0010240	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_666129.1	Gene:	Gabrp / 216643	MGIID:	2387597	Length:	440	Species:	Mus musculus

Alignment Length:	463	Identity:	177/463 - (38%)
Similarity:	254/463 - (54%)	Gaps:	81/463 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 NILQGYDIRLRPNFGGEPLHVGMDLTIASFDAISEVNMDYTITMYLNQYWRDERLAFNIFGQYFD 110
            |:..||:..|||||||:|:.:.:.|.|||..:|||.|||||.|:||.|.|.|.||.|
Mouse    43 NLTAGYNKFLRPNFGGDPVRIALTLDIASISSISESNMDYTATIYLRQRWTDPRLVF-------- 99

  Fly   111 DENDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKLVRLGGDGAVTYGMRFTTTLA 175
                :| :...||.....|.:|||||:....|.||||:||..|:|:||..:|.|.|.:|.|||:.
Mouse   100 ----EG-NKSFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVT 159

  Fly   176 CMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYW--KPTPVRGVEDAELPQFTIIGYETNDRKERL 238
            |.|||..||:|:|.|.:::||:||..:||...|  ....|||:|:..|.|:||..|.|.....:.
Mouse   160 CNMDLSKYPMDTQTCKLQLESWGYDGNDVEFSWLRGNDSVRGLENLRLAQYTIQQYFTLVTVSQQ 224

  Fly   239 ATGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHEATSARVALGITTVLTMTTIS 303
            .||.|.||.|.|:|:||:.||:.:||:||..:|:||||||||:.::..||..:|:||||:|||:.
Mouse   225 ETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVTTVLSMTTLM 289

  Fly   304 TGVRSSLPRIS-YVKAIDIYLVMCFVFVFAALLEYAAVNYTYWGKRAKKKIKKVKECCPGKIGKS 367
            .|.|:|||..: ::||||:||.:||.|||.||||||..:|:...:.|      ||:..|.|  .|
Mouse   290 IGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQMA------VKDRGPAK--DS 346

  Fly   368 ERSETCSTTEDIIELQDVRMSPIPSLRRGTYNATLDSIGTE------TMNLG-KFPPSFR--ITR 423
            |.          :.:.::..|.|.|.:|....|:::..|..      ||... ||...||  |:|
Mouse   347 EE----------VNITNIINSSISSFKRKISFASIEISGDNVNYSDLTMKASDKFKFVFREKISR 401

  Fly   424 --NYGTGHSQLRRRAQRGISTRPRMLHALKRGASAIKATIPKIKDVNIIDKYSRMIFPISFLAFN 486
              :|.|                                    |::.:.:|:||:::||:.|:..|
Mouse   402 IIDYFT------------------------------------IQNPSNVDRYSKLLFPLIFMLAN 430

  Fly   487 LGYWLFYI 494
            :.||.:|:
Mouse   431 VFYWAYYM 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	176/460 (38%)
		Neur_chan_LBD	47..256	CDD:280998	93/210 (44%)
		Neur_chan_memb	263..490	CDD:280999	77/238 (32%)
Gabrp	NP_666129.1	Neur_chan_LBD	41..242	CDD:280998	94/211 (45%)
		LIC	43..437	CDD:273305	176/460 (38%)
		Neur_chan_memb	249..434	CDD:280999	77/238 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D226476at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920