Protein Alignment Lcch3 and GABRR3

DIOPT Version :9

• Sequence 1: NP_996469.1
• Gene: Lcch3 / 32554
• FlyBaseID: FBgn0010240
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_001099050.1
• Gene: GABRR3 / 200959
• HGNCID: 17969
• Length: 467
• Species: Homo sapiens
• Alignment Length: 486
• Identity: 180/486 - (37%)
• Similarity: 261/486 - (53%)
• Gaps: 76/486 - (15%)

  Fly    23 QLIRCIRKDVLAGRLENVTQTISNILQGYDIRLRPNFGGEPLHVGMDLTIASFDAISEVNMDYTI 87
            |..|..:.|....|.:...|.:.  ::..|..:||.|||.|:.||:|:.:.|.|:|||.|||:|:
Human    44 QETRMKKDDSTKARPQKYEQLLH--IEDNDFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTM 106

  Fly    88 TMYLNQYWRDERLAFNIFGQYFDDENDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTER 152
            |.||..||:||||:|           ....:..:|.......||||||.||.:.|.||:||.|..
Human   107 TFYLRHYWKDERLSF-----------PSTANKSMTFDHRLTRKIWVPDIFFVHSKRSFIHDTTME 160

  Fly   153 NKLVRLGGDGAVTYGMRFTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYWK--PTPVRG 215
            |.::|:..||.|...:|.|.:..|.||...:|||:|||::|:|||.|...|:::|||  ...:..
Human   161 NIMLRVHPDGNVLLSLRITVSAMCFMDFSRFPLDTQNCSLELESYAYNEDDLMLYWKHGNKSLNT 225

  Fly   216 VEDAELPQFTIIGYETNDRKERLA----TGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWV 276
            .|...|.||.|   |.......||    ||.|.||.::|.|:|::.:||.|||.|:||:||||||
Human   226 EEHMSLSQFFI---EDFSASSGLAFYSSTGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWV 287

  Fly   277 SFWINHEATSARVALGITTVLTMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVN 341
            ||||:..|..|||:|||||||||:||.|.|.:|:|::||:||:|:||.:..:|||.:::||||||
Human   288 SFWIDRRAVPARVSLGITTVLTMSTIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVN 352

  Fly   342 YTYWGKRAKKKIKKVKECCPGKIGKSERSETCSTTEDIIELQDVRMSPIPSLRR----GTYNATL 402
            |....:. :|:.||.     |||.                    ||..|.:::.    |.|:
Human   353 YLTTVEE-RKQFKKT-----GKIS--------------------RMYNIDAVQAMAFDGCYH--- 388

  Fly   403 DS-IGTETMNLGKFPPSFRITRNY---GTGHSQLRRRAQRGISTRPRMLHALKRGASAIKATIPK 463
            || |..:..:|......|...::.   .|..|:::||...|               ..:...|
Human   389 DSEIDMDQTSLSLNSEDFMRRKSICSPSTDSSRIKRRKSLG---------------GHVGRII-- 436

  Fly   464 IKDVNIIDKYSRMIFPISFLAFNLGYWLFYI 494
            :::.::||.|||::|||.::.|||.||..|:
Human   437 LENNHVIDTYSRILFPIVYILFNLFYWGVYV 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	179/483 (37%)
		Neur_chan_LBD	47..256	CDD:280998	85/214 (40%)
		Neur_chan_memb	263..490	CDD:280999	84/234 (36%)
GABRR3	NP_001099050.1	LIC	55..466	CDD:273305	176/472 (37%)
		Neur_chan_LBD	59..267	CDD:280998	86/223 (39%)
		Neur_chan_memb	274..463	CDD:280999	84/234 (36%)
		Interaction with SQSTM1. /evidence=ECO:0000250	347..448		32/146 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D226476at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920