DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lcch3 and Gabrr3

DIOPT Version :9

Sequence 1:	NP_996469.1	Gene:	Lcch3 / 32554	FlyBaseID:	FBgn0010240	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_620252.1	Gene:	Gabrr3 / 192258	RGDID:	621564	Length:	464	Species:	Rattus norvegicus

Alignment Length:	456	Identity:	173/456 - (37%)
Similarity:	257/456 - (56%)	Gaps:	64/456 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 LQGYDIRLRPNFGGEPLHVGMDLTIASFDAISEVNMDYTITMYLNQYWRDERLAFNIFGQYFDDE 112
            ::.:|...||.|||.|:.||:|:.:.|.|:|||||||:|:|.||..||:||||:|
  Rat    64 IEDHDFSTRPGFGGSPVPVGIDVQVESIDSISEVNMDFTMTFYLRHYWKDERLSF---------- 118

  Fly   113 NDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKLVRLGGDGAVTYGMRFTTTLACM 177
             ....:..:|......:||||||.||.:.|.||:||.|..|.::|:..||.|.:.:|.|.:..|.
  Rat   119 -PSTTNKSMTFDRRLIQKIWVPDIFFVHSKRSFIHDTTVENIMLRVHPDGNVLFSLRITVSAMCF 182

  Fly   178 MDLHYYPLDSQNCTVEIESYGYTVSDVVMYWK--PTPVRGVEDAELPQFTIIGYETNDRKERLA- 239
            ||...:|||:|||::|:|||.|...|:::|||  ...:...|...|.||.|   |.......||
  Rat   183 MDFSRFPLDTQNCSLELESYAYNEEDLMLYWKHGNKSLNTEEHISLSQFFI---EEFSASSGLAF 244

  Fly   240 ---TGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHEATSARVALGITTVLTMTT 301
               ||.|.||.::|.|:|:|.:||.|||.|::|:||||||||||:..|..|||:|||||||||:|
  Rat   245 YSSTGWYYRLFINFVLRRHIFFFVLQTYFPAMLMVMLSWVSFWIDRRAVPARVSLGITTVLTMST 309

  Fly   302 ISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVNYTYWGKRAKKKIKKVKECCPGKIGK 366
            |.|||.:|:|::|||||:|:|:.:..:|||.:::|||||||....:..|:..::      |||
  Rat   310 IVTGVSASMPQVSYVKAVDVYMWVSSLFVFLSVIEYAAVNYLTTVEEWKQLNRR------GKI-- 366

  Fly   367 SERSETCSTTEDIIELQDVRMSPIPSLRRGTYNATLDSIGTETMNLGKFPPSFRITRNYGT---G 428
                   |...:|..:|.:...       |.|:.....:...:..|.....|.| |:..|:   .
  Rat   367 -------SGMYNIDAVQAMAFD-------GCYHDGETDVDQTSFFLHSEEDSMR-TKFTGSPCAD 416

  Fly   429 HSQLRRRAQRGISTRPRMLHALKRGASAIKATIPKIKDVNIIDKYSRMIFPISFLAFNLGYWLFY 493
            .||::|::..|  ...|::                :::.::||.|||::||:.::.|||.||..|
  Rat   417 SSQIKRKSLGG--NVGRII----------------LENNHVIDTYSRIVFPVVYIIFNLFYWGIY 463

  Fly   494 I 494
            :
  Rat   464 V 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	172/453 (38%)
		Neur_chan_LBD	47..256	CDD:280998	86/213 (40%)
		Neur_chan_memb	263..490	CDD:280999	80/229 (35%)
Gabrr3	NP_620252.1	LIC	58..463	CDD:273305	172/453 (38%)
		LGIC_ECD	79..264	CDD:355788	80/198 (40%)
		Cys-loop	181..195	CDD:349787	7/13 (54%)
		Interaction with SQSTM1. /evidence=ECO:0000269\|PubMed:12431995	344..445		29/141 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D226476at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920