DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lcch3 and glc-3

DIOPT Version :9

Sequence 1:	NP_996469.1	Gene:	Lcch3 / 32554	FlyBaseID:	FBgn0010240	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_504441.1	Gene:	glc-3 / 178930	WormBaseID:	WBGene00001593	Length:	484	Species:	Caenorhabditis elegans

Alignment Length:	498	Identity:	155/498 - (31%)
Similarity:	236/498 - (47%)	Gaps:	95/498 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 TQTISNIL-QGYDIRLRP---------NFGGEPLHVGMDLTIASFDAISEVNMDYTITMYLNQYW 95
            |:.|..:| :|||.|:||         ..|...::|.|  .|.|...|.:|||:|::.:...:.|
Worm    28 TEIIKKLLGKGYDWRVRPPGINLTIPGTHGAVIVYVNM--LIRSISKIDDVNMEYSVQLTFREEW 90

  Fly    96 RDERLAFNIFGQYFDDENDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKLVRLGG 160
            .|.|||:...|        |...|.|.|:.  .::||:||:||.|:|.:..||:.:.|.|:|:..
Worm    91 VDGRLAYGFPG--------DSTPDFLILTA--GQQIWMPDSFFQNEKQAHKHDIDKPNVLIRIHR 145

  Fly   161 DGAVTYGMRFTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYWKPT-PV---RGVEDAEL 221
            ||.:.|.:|.:..|:|.|.|.|||:|.|.|.:::.||.||.:|:...||.| ||   :|:. :.|
Worm   146 DGRILYSVRISMVLSCPMHLQYYPMDVQTCLIDLASYAYTENDIEYRWKKTDPVQLKKGLH-SSL 209

  Fly   222 PQFTIIGYETNDRKERLATGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHEATS 286
            |.|.:...:|.....:..||.|..|....:|:|...|::.|.|:||.::|::||||||::..|..
Worm   210 PSFELNNVDTTLCTSKTNTGTYSCLRTVLELRRQFSYYLLQLYIPSTMLVIVSWVSFWLDRGAVP 274

  Fly   287 ARVALGITTVLTMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVNYTYWGKRAKK 351
            |||.||:||:|||||.::|:.:.||.:||.||||:::..|..|:|.||||:|.|  ||...|:..
Worm   275 ARVTLGVTTLLTMTTQASGINAKLPPVSYTKAIDVWIGACLTFIFGALLEFAWV--TYISSRSFY 337

  Fly   352 KIKKVKECCPGKIGKSERSETCSTTED-IIELQDVRMSPIPSLRRGTYNATLDSIGTET-MNLGK 414
            |                |::.||:... :||.:...:.|      .|..|.......|. |.|.:
Worm   338 K----------------RNKNCSSRNSLLIETKQALIIP------NTVVAQFPEHPEEVEMGLAQ 380

  Fly   415 FPPSFRITRNYGTGHSQLRRRAQRGISTRPRMLHALKRGASAIKATI-------------PKIKD 466
            .|..:  .|..|.|.:..|...           |.......|.:..|             ...::
Worm   381 APDVW--IRQSGNGKTVSRVNG-----------HINHNNDEAAELIIFDAKHKNRRFVWWTNFRN 432

  Fly   467 VNII----------------DKYSRMIFPISFLAFNLGYWLFY 493
            :.:|                |..||::||..|:.||..||..|
Worm   433 IRLIRWIRNRLNVDDNAKRADLISRVLFPTLFVCFNFVYWTKY 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	154/496 (31%)
		Neur_chan_LBD	47..256	CDD:280998	75/222 (34%)
		Neur_chan_memb	263..490	CDD:280999	73/257 (28%)
glc-3	NP_504441.1	LIC	29..475	CDD:273305	153/495 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810