Protein Alignment Lcch3 and acc-4

DIOPT Version :9

• Sequence 1: NP_996469.1
• Gene: Lcch3 / 32554
• FlyBaseID: FBgn0010240
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_001379219.1
• Gene: acc-4 / 176778
• WormBaseID: WBGene00012099
• Length: 408
• Species: Caenorhabditis elegans
• Alignment Length: 472
• Identity: 106/472 - (22%)
• Similarity: 190/472 - (40%)
• Gaps: 124/472 - (26%)

  Fly    27 CIRKDVLAGRLENVTQTISNILQGYDIRLRPNFGGEPLHVGMDLTIASFDAISEVNMDYTITMYL 91
            |:..|.:          |:.||.||:....|  ||..:.|.:::.:.....|.|:..::.:.:|:
 Worm    49 CMGDDAI----------IAQILDGYNKLDLP--GGGHVVVSIEIWVQEVSKIIEITSEFELDIYV 101

  Fly    92 NQYWRDERLAFNIFGQYFDDENDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKLV 156
            .:.|.|..||::.......:.:.||.:        ...|||.|...|.|.|.:.:|:...:|..:
 Worm   102 TERWTDPSLAYSHLNPCKSNMSVDGAT--------ILNKIWNPHACFVNSKLANIHESPFKNIFL 158

  Fly   157 RLGGDGAVTYGMRFTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYWKPT--PVRGVE-D 218
            ::..:|::.:..|...|..|...|..:|:|.|.|.:..||:.:....|.|.|..|  |:..:: :
 Worm   159 QIYSNGSIWHNYRIKLTGPCSSTLRTFPIDQQRCMLFYESFTHNTDQVKMEWITTVPPITILKGN 223

  Fly   219 AELPQFTIIGYETNDRKERLATGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHE 283
            ..||.:.::.:.::........|::..|..:|..||..|:::.|.|:|:.:.|.:|||||.:..|
 Worm   224 ITLPDYVLVDFSSSSELRLYPPGIFNELIATFTFQRLYGFYILQVYVPAYISVFISWVSFTLGAE 288

  Fly   284 ATSARVALGITTVLTMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVNYTYWGKR 348
            ...:|..:|:.::|.:|.....|.::||:.|.|||||::::....|:||:|:|.|.|.|
 Worm   289 QIPSRTTVGVNSLLALTFQFGAVVNNLPKTSDVKAIDVWILSSMAFIFASLIELAVVGY------ 347

  Fly   349 AKKKIKKVKECCPGKIGKSERSETCSTTEDIIELQDVRMSPIPSLRRGTYNATLDSIGTETMNLG 413
                                                                             
 Worm   348 ----------------------------------------------------------------- 347

  Fly   414 KFPPSFRITRNYGTGHSQLRRRAQRG-ISTRPRMLHALKRGASAIKATIPKIKDVNIIDKYSRMI 477
                              |.|..|.| |..|...|....:..:|:|           ||:.|.::
 Worm   348 ------------------LSRDGQHGSIKCRCSWLCMNCKDWTALK-----------IDQMSSIV 383

  Fly   478 FPISFLAFNLGYWLFYI 494
            ||:||||||:.||..::
 Worm   384 FPVSFLAFNIWYWFIFL 400

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	106/469 (23%)
		Neur_chan_LBD	47..256	CDD:280998	49/211 (23%)
		Neur_chan_memb	263..490	CDD:280999	50/227 (22%)
acc-4	NP_001379219.1	LGIC_ECD_GABAAR	74..259	CDD:349791	40/192 (21%)
		LGIC_TM_anion	263..396	CDD:349851	51/232 (22%)
		TM1 helix	266..286	CDD:349851	9/19 (47%)
		TM2 helix	295..316	CDD:349851	4/20 (20%)
		TM3 helix	326..348	CDD:349851	8/110 (7%)
		TM4 helix	375..396	CDD:349851	12/31 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810