Protein Alignment Lcch3 and gab-1

DIOPT Version :9

• Sequence 1: NP_996469.1
• Gene: Lcch3 / 32554
• FlyBaseID: FBgn0010240
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_499661.2
• Gene: gab-1 / 176691
• WormBaseID: WBGene00001512
• Length: 550
• Species: Caenorhabditis elegans
• Alignment Length: 508
• Identity: 263/508 - (51%)
• Similarity: 338/508 - (66%)
• Gaps: 64/508 - (12%)

  Fly    39 NVTQTISNILQGYDIRLRPNFGGEPLHVGMDLTIASFDAISEVNMDYTITMYLNQYWRDERLAFN 103
            |.:..:|::|..|||||||.|||:.|.:.||:.|||||:||||:||||:||||:|||.||||.::
 Worm    53 NASSLLSDLLLDYDIRLRPGFGGDALLLTMDIIIASFDSISEVDMDYTLTMYLHQYWTDERLRWS 117

  Fly   104 IFGQYFDDENDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKLVRLGGDGAVTYGM 168
                     |:..| |.:||||:|::.|||||||.||||:|:||:||||||::|:..||.|.|||
 Worm   118 ---------NEIPI-DEMTLSGEFSQNIWVPDTFLANDKHSYLHEVTERNKMLRINVDGKVAYGM 172

  Fly   169 RFTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYWK-PTPVRGVEDAELPQFTIIGYETN 232
            |.|:||:|.|:|..:|||||||||||||||||.|:|:|.|. |..|.|||.|::|||||.|:.|.
 Worm   173 RLTSTLSCSMNLRNFPLDSQNCTVEIESYGYTTSEVLMKWNYPLAVHGVEQADVPQFTITGFHTE 237

  Fly   233 DRKERLATGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHEATSARVALGITTVL 297
            |.....|||.||||||.|:|:|::|||:||||||.:|||||||||||||||||||||||||||||
 Worm   238 DSIVSTATGSYQRLSLVFQLRRSVGYFIFQTYLPCVLIVMLSWVSFWINHEATSARVALGITTVL 302

  Fly   298 TMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVNYTYWG---------------- 346
            ||||||||||.|||||||||:||||||||||||||||||||||||:|||
 Worm   303 TMTTISTGVRQSLPRISYVKSIDIYLVMCFVFVFAALLEYAAVNYSYWGRERGKGGGGNEWPVNG 367

  Fly   347 --KRAKKKIKKVKECCPG------------KIGKSERSETCSTT-------EDIIELQDVRMSPI 390
              |..::....|::..|.            ::...|.:.:.|.|       |...:.:....|||
 Worm   368 ANKEDRESAVNVQKWVPSGLMDGVPQPQDRRVEALEEAMSTSNTAAQNNNFESTSKPKKRSSSPI 432

  Fly   391 PSLRRGTYNATLDSIGTE-----TMNLGKFPPSFRITRNYGTGHSQLR--RRAQRGISTRPRMLH 448
            |.|.|.....:.:|...:     |.:|....|  ..:.|:.|.|.:.|  .||:|.: |..||..
 Worm   433 PPLCRAGNTISEESESPDYPRYSTTSLKGARP--HASLNHKTHHLKGRSSARAKRRM-TLARMNV 494

  Fly   449 ALKRGASAI----KATIP--KIKDVNIIDKYSRMIFPISFLAFNLGYWLFYIL 495
            ::|:..|.|    :..||  :::|||:||||||::||:.|:.|||.||.:|::
 Worm   495 SMKQSISGIGRRARKVIPTIRVRDVNLIDKYSRVVFPVCFIVFNLFYWSYYMM 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	262/504 (52%)
		Neur_chan_LBD	47..256	CDD:280998	127/209 (61%)
		Neur_chan_memb	263..490	CDD:280999	126/276 (46%)
gab-1	NP_499661.2	LIC	67..545	CDD:273305	257/490 (52%)
		Neur_chan_LBD	68..259	CDD:280998	122/200 (61%)
		Neur_chan_memb	268..542	CDD:280999	126/276 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166711
Domainoid	1	1.000	255	1.000	Domainoid score	I1099
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H633
Inparanoid	1	1.050	463	1.000	Inparanoid score	I863
Isobase	1	0.950	-	0	Normalized mean entropy	S3621
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D226476at33208
OrthoFinder	1	1.000	-	-		FOG0001081
OrthoInspector	1	1.000	-	-		oto18063
orthoMCL	1	0.900	-	-		OOG6_101786
Panther	1	1.100	-	-	LDO	PTHR18945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2537
SonicParanoid	1	1.000	-	-		X650
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740