DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lcch3 and Gabrg3

DIOPT Version :9

Sequence 1:	NP_996469.1	Gene:	Lcch3 / 32554	FlyBaseID:	FBgn0010240	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	XP_017177467.1	Gene:	Gabrg3 / 14407	MGIID:	95624	Length:	468	Species:	Mus musculus

Alignment Length:	524	Identity:	169/524 - (32%)
Similarity:	251/524 - (47%)	Gaps:	105/524 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LGAQLQLIRCI----------------------RKDVLAGRLE--NVTQTISNILQGYDIRLRPN 58
            :.|:|.|:.|:                      :|.|||.:.:  :||..::.:|:.||.:|||:
Mouse     1 MAAKLLLLLCLFSGLHARSRRVEEDENEDSPSNQKWVLAPKSQDTDVTLILNKLLREYDKKLRPD 65

  Fly    59 FGGEPLHVGMDLTIASFDAISEVNMDYTITMYLNQYWRDERLAFNIFGQYFDDENDDGISDVLTL 123
            .|.:|..:.:|:.:.|...:|.:||:|.|.::..|.|.|.||.||            ....:|||
Mouse    66 IGIKPTVIDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRLRFN------------STMKILTL 118

  Fly   124 SGDFAEKIWVPDTFFANDKNSFLHDVTERNKLVRLGGDGAVTYGMRFTTTLACMMDLHYYPLDSQ 188
            :.:....||:|||.|.|.|.:..|.:|..|:|:|:..||.:.|.:|.|....|.:.||.:|:|:.
Mouse   119 NSNMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLRLTINAECQLQLHNFPMDAH 183

  Fly   189 NCTVEIESYGYTVSDVVMYWKPTPVRGVEDA--ELPQFTIIGYETNDRKERLATGVYQRLSLSFK 251
            .|.:...||||...:::..|:...|...:..  .|.||..:|..........:.|.|..:::.|:
Mouse   184 ACPLTFSSYGYPKEEMIYRWRKNSVEAADQKSWRLYQFDFMGLRNTTEIVTTSAGDYVVMTIYFE 248

  Fly   252 LQRNIGYFVFQTYLPSILIVMLSWVSFWINHEATSARVALGITTVLTMTTISTGVRSSLPRISYV 316
            |.|.:|||..|||:|.||.|:||||||||..:||.||..|||||||||||:||..|.||||:|||
Mouse   249 LSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDATPARTTLGITTVLTMTTLSTIARKSLPRVSYV 313

  Fly   317 KAIDIYLVMCFVFVFAALLEYAAVNYTYWGKRAKKKIKKVKECCPGKIGKSERSETCSTTEDIIE 381
            .|:|:::.:||:||||||:|||.:|  |:....|..|:|.|                  |..::.
Mouse   314 TAMDLFVTVCFLFVFAALMEYATLN--YYSSCRKPTIRKKK------------------TSQLLH 358

  Fly   382 LQDVRMSPIP-SLRRGTYNATLDSIGTETMNLGKFPPSFRITRNYGTGHSQLR------------ 433
            ....|..|.. ||:..:..:.||.         :.||...||.|......:..
Mouse   359 PDSTRWIPDRISLQAPSNYSLLDM---------RPPPPVMITLNNSMYWQEFEDTCVYECLDGKD 414

  Fly   434 --------RRAQRGISTRPRMLHALKRGASAIKATIPKIKDVNIIDKYSRMIFPISFLAFNLGYW 490
                    ...:.|         :.:||...|        ||:.:|.|||:.||.|||.|||.||
Mouse   415 CQSFFCCYEECKSG---------SWRRGRIHI--------DVSELDSYSRVFFPTSFLLFNLVYW 462

  Fly   491 LFYI 494
            :.|:
Mouse   463 VGYL 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	168/521 (32%)
		Neur_chan_LBD	47..256	CDD:280998	64/210 (30%)
		Neur_chan_memb	263..490	CDD:280999	88/247 (36%)
Gabrg3	XP_017177467.1	LIC	50..465	CDD:273305	158/472 (33%)
Gabrg3	XP_017177467.1	LGIC_ECD_GABAAR_G	71..252	CDD:349801	55/192 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810