DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lcch3 and Gabrd

DIOPT Version :9

Sequence 1:	NP_996469.1	Gene:	Lcch3 / 32554	FlyBaseID:	FBgn0010240	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	XP_006538609.2	Gene:	Gabrd / 14403	MGIID:	95622	Length:	483	Species:	Mus musculus

Alignment Length:	474	Identity:	181/474 - (38%)
Similarity:	265/474 - (55%)	Gaps:	63/474 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 DVLAGRLE-NVTQTISNILQGYDIRLRPNFGGEPLHVGMDLTIASFDAISEVNMDYTITMYLNQY 94
            |.:...|| :....:..:::||....||..||.|::|.:.|.:||.|.|||.||:||:|::|:|.
Mouse    64 DYVGSNLEISWLPNLDGLMEGYARNFRPGIGGAPVNVALALEVASIDHISEANMEYTMTVFLHQS 128

  Fly    95 WRDERLAFNIFGQYFDDENDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKLVRLG 159
            |||.||::|            ..::.|.|...|.:|:|:||||..|.|:::.||||..|||:||.
Mouse   129 WRDSRLSYN------------HTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQ 181

  Fly   160 GDGAVTYGMRFTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYWKPT--PVRGVEDAELP 222
            .||.:.|.:|.|:|:||.|||..||||.|.|.:::|||||:..|:|.||...  .:.|::..:|.
Mouse   182 PDGVILYSIRITSTVACDMDLAKYPLDEQECMLDLESYGYSSEDIVYYWSENQEQIHGLDRLQLA 246

  Fly   223 QFTIIGYE-TNDRKERLATGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHEATS 286
            ||||..|. |.:.....:.|.:.||||.|:|:||.|.::.|:|:||:|:|.:|||||||:..|..
Mouse   247 QFTITSYRFTTELMNFKSAGQFPRLSLHFQLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVP 311

  Fly   287 ARVALGITTVLTMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVNYTY-WGKRAK 350
            |||:|||||||||||:....||||||.|.:||:|:|..:|:|||||||:|||..::.. :.|:.|
Mouse   312 ARVSLGITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHFNADYRKKRK 376

  Fly   351 KKIKKVKECCPGKIGKSERSETCSTTEDIIELQDVRMSPIPSLRRGTYNA----TLDSIGTETMN 411
            .|:|..|          .|:|           .|||            ||    :|.:.|. :..
Mouse   377 AKVKVTK----------PRAE-----------MDVR------------NAIVLFSLSAAGV-SQE 407

  Fly   412 LGKFPPSFRITRNYGTGHSQLRRRAQRGISTRPRMLHALKRGASAIKATIPKIKDVNIIDKYSRM 476
            |.......|:..|....:..:...|::...:||       .|...|::.:..| |.:.||.|:|.
Mouse   408 LAISRRQGRVPGNLMGSYRSVEVEAKKEGGSRP-------GGPGGIRSRLKPI-DADTIDIYARA 464

  Fly   477 IFPISFLAFNLGYWLFYIL 495
            :||.:|.|.|:.||..|.:
Mouse   465 VFPAAFAAVNIIYWAAYTM 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	180/470 (38%)
		Neur_chan_LBD	47..256	CDD:280998	90/211 (43%)
		Neur_chan_memb	263..490	CDD:280999	82/231 (35%)
Gabrd	XP_006538609.2	LGIC_ECD	97..280	CDD:355788	83/194 (43%)
		Cys-loop	198..212	CDD:349787	9/13 (69%)
		LGIC_TM_GABAAR_delta	283..>371	CDD:349857	50/87 (57%)
		TM1 helix	286..306	CDD:349857	12/19 (63%)
		TM2 helix	315..336	CDD:349857	14/20 (70%)
		TM3 helix	346..368	CDD:349857	12/21 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910