DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lcch3 and Gabrb2

DIOPT Version :9

Sequence 1:	NP_996469.1	Gene:	Lcch3 / 32554	FlyBaseID:	FBgn0010240	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001334243.1	Gene:	Gabrb2 / 14401	MGIID:	95620	Length:	512	Species:	Mus musculus

Alignment Length:	498	Identity:	239/498 - (47%)
Similarity:	310/498 - (62%)	Gaps:	65/498 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 VTQTISNILQGYDIRLRPNFGGEPLHVGMDLTIASFDAISEVNMDYTITMYLNQYWRDERLAFNI 104
            |.:|:..:|:||||||||:|||.|:.|||::.|||.|.:||||||||:|||..|.|||:||::|:
Mouse    36 VKETVDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNV 100

  Fly   105 FGQYFDDENDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKLVRLGGDGAVTYGMR 169
                        |...|||....|:::|||||:|.|||.||:|.||.:|:::||..||.|.||:|
Mouse   101 ------------IPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLR 153

  Fly   170 FTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYWK--PTPVRGVEDAELPQFTIIGYETN 232
            .|||.||||||..||||.||||:||||||||..|:..||:  ...|.||...|||||:|:.|:..
Mouse   154 ITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLI 218

  Fly   233 DRKERLATGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHEATSARVALGITTVL 297
            .:|...:||.|.||||||||:||||||:.|||:|||||.:|||||||||::|::|||||||||||
Mouse   219 TKKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVL 283

  Fly   298 TMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVNYTYWGK---RAKKKIKKVKEC 359
            |||||:|.:|.:||:|.||||||:||:.||||||.||||||.|||.::|:   |.||..:|....
Mouse   284 TMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAANA 348

  Fly   360 CPGKI---------------GKSER---------SETCSTTEDIIELQDVRMSPIPSLRRGTYN- 399
            ...|:               |...|         |.|..||.....|  ..|.|..::...|..
Mouse   349 NNEKMRLDVNKMFYKDIKQNGTQYRSLWDPTGDLSPTRRTTNYDFSL--YTMDPHENILLSTLEI 411

  Fly   400 ----ATLDSIGTETMNLGKFPPSFRIT--------RNYG-TGHSQLRRRAQRGISTRPRMLHALK 451
                ||.:::    |.||. |.|..:.        |..| ..||..|...:|.::.:.   ..|:
Mouse   412 KNEMATSEAV----MGLGD-PRSTMLAYDASSIQYRKAGLPRHSFGRNALERHVAQKK---SRLR 468

  Fly   452 RGASAIKATIPKIKDVNIIDKYSRMIFPISFLAFNLGYWLFYI 494
            |.||.:|.|||.:.|||.||::||:.||:.|..||:.|||:|:
Mouse   469 RRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYV 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	238/495 (48%)
		Neur_chan_LBD	47..256	CDD:280998	117/210 (56%)
		Neur_chan_memb	263..490	CDD:280999	110/267 (41%)
Gabrb2	NP_001334243.1	LIC	9..510	CDD:273305	238/495 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	248	1.000	Domainoid score	I2131
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	435	1.000	Inparanoid score	I1681
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D226476at33208
OrthoFinder	1	1.000	-	-		FOG0001081
OrthoInspector	1	1.000	-	-		otm42910
orthoMCL	1	0.900	-	-		OOG6_101786
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2537
SonicParanoid	1	1.000	-	-		X650
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.860