DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lcch3 and Gabrb1

DIOPT Version :9

Sequence 1:	NP_996469.1	Gene:	Lcch3 / 32554	FlyBaseID:	FBgn0010240	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_032095.1	Gene:	Gabrb1 / 14400	MGIID:	95619	Length:	474	Species:	Mus musculus

Alignment Length:	498	Identity:	232/498 - (46%)
Similarity:	316/498 - (63%)	Gaps:	46/498 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SCGLFFFLLGAQLQLIRCIRKDVLAGRLENVTQTISNILQGYDIRLRPNFGGEPLHVGMDLTIAS 74
            |.||..|  ...:.::.|.........:..|.:|:..:|:||||||||:|||.|:.|||.:.:||
Mouse     9 SLGLLSF--PVMVAMVCCAHSSNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPPVDVGMRIDVAS 71

  Fly    75 FDAISEVNMDYTITMYLNQYWRDERLAFNIFGQYFDDENDDGISDVLTLSGDFAEKIWVPDTFFA 139
            .|.:||||||||:|||..|.|:|:||:::            ||...|||....|:::|||||:|.
Mouse    72 IDMVSEVNMDYTLTMYFQQSWKDKRLSYS------------GIPLNLTLDNRVADQLWVPDTYFL 124

  Fly   140 NDKNSFLHDVTERNKLVRLGGDGAVTYGMRFTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDV 204
            |||.||:|.||.:|:::||..||.|.||:|.|||.||||||..||||.||||:||||||||..|:
Mouse   125 NDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDI 189

  Fly   205 VMYWK--PTPVRGVEDAELPQFTIIGYETNDRKERLATGVYQRLSLSFKLQRNIGYFVFQTYLPS 267
            ..||.  ...|.||...|||||:|:.|:...:|....||.|.||||||:|:||||||:.|||:||
Mouse   190 EFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLKRNIGYFILQTYMPS 254

  Fly   268 ILIVMLSWVSFWINHEATSARVALGITTVLTMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFA 332
            .||.:|||||||||::|::||||||||||||||||||.:|.:||:|.|||||||||:.||||||.
Mouse   255 TLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFL 319

  Fly   333 ALLEYAAVNYTYWGKRAKKKIKKVKECCPGKIGKSERSETCSTTEDIIELQDVRMSPIPSLRRGT 397
            ||||||.|||.::||..:||            |.|::.:: :..::.:|:..|::....::...|
Mouse   320 ALLEYAFVNYIFFGKGPQKK------------GASKQDQS-ANEKNRLEMNKVQVDAHGNILLST 371

  Fly   398 YNATLDSIGTETMNLGKFPPSFRITRNYGTGHSQLRRRA-----------QRGISTRPRMLHALK 451
            .....::.|:|.:. |...|...: .:|.:...|.|:..           :.|:..:.|    ::
Mouse   372 LEIRNETSGSEVLT-GVSDPKATM-YSYDSASIQYRKPLSSREGFGRGLDRHGVPGKGR----IR 430

  Fly   452 RGASAIKATIPKIKDVNIIDKYSRMIFPISFLAFNLGYWLFYI 494
            |.||.:|..||.:.|||.|||:|||.|||:|..||:.|||:|:
Mouse   431 RRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYV 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	228/490 (47%)
		Neur_chan_LBD	47..256	CDD:280998	114/210 (54%)
		Neur_chan_memb	263..490	CDD:280999	101/237 (43%)
Gabrb1	NP_032095.1	LIC	9..472	CDD:273305	231/495 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	248	1.000	Domainoid score	I2131
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	435	1.000	Inparanoid score	I1681
Isobase	1	0.950	-	0	Normalized mean entropy	S3621
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D226476at33208
OrthoFinder	1	1.000	-	-		FOG0001081
OrthoInspector	1	1.000	-	-		otm42910
orthoMCL	1	0.900	-	-		OOG6_101786
Panther	1	1.100	-	-	LDO	PTHR18945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2537
SonicParanoid	1	1.000	-	-		X650
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.810