DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lcch3 and Gabra3

DIOPT Version :9

Sequence 1:	NP_996469.1	Gene:	Lcch3 / 32554	FlyBaseID:	FBgn0010240	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001344745.1	Gene:	Gabra3 / 14396	MGIID:	95615	Length:	523	Species:	Mus musculus

Alignment Length:	483	Identity:	167/483 - (34%)
Similarity:	244/483 - (50%)	Gaps:	77/483 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 DVLAGRLENV---TQTISNILQGYDIRLRPNFGGEPLHVGMDLTIASFDAISEVNMDYTITMYLN 92
            |:.....:|:   |:.:..:|.|||.||||..|.....|..|:.:.||..:|:.:|:|||.::..
Mouse    86 DIPDDSTDNITIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFR 150

  Fly    93 QYWRDERLAFNIFGQYFDDENDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKLVR 157
            |.|.||||.|            ||...:|.|:...|.|||.|||||.|.|.|..|::|..|||:|
Mouse   151 QTWHDERLKF------------DGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLR 203

  Fly   158 LGGDGAVTYGMRFTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYWKPTPVRGVEDAE-- 220
            |..:|.:.|.||.|....|.|.|..:|:|...|.::..||.||.::|:..|.....:.||.|:
Mouse   204 LVDNGTLLYTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTKAEVIYSWTLGKNKSVEVAQDG 268

  Fly   221 --LPQFTIIGYETNDRKERLATGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHE 283
              |.|:.::|:.......|.:||.|..::..|.|:|.|||||.|||||.|:.|:||.||||:|.|
Mouse   269 SRLNQYDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRE 333

  Fly   284 ATSARVALGITTVLTMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVNY---TYW 345
            :..||...|:||||||||:|...|:|||:::|..|:|.::.:|:.|||:||:|:|.|||   ..|
Mouse   334 SVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRSW 398

  Fly   346 GKRAKK-----KIKKVKECCPGKIGKSERSETCSTTEDIIELQDVRMSPIPSLRRGTYNATLDSI 405
            ....||     ::||.....|.|                                  .|.|.:.:
Mouse   399 AWEGKKVPEALEMKKKTPAAPTK----------------------------------KNTTFNIV 429

  Fly   406 GTE-TMNLGKFPPSFRITRNYGTGHSQLRRRAQRGISTRPRMLHALKRGASAIKATIPKIK---D 466
            ||. .:||.|......|:::          .|....|:.|..:.:.|  |:.::.:..:.|   .
Mouse   430 GTTYPINLAKDTEFSTISKS----------AAAPSASSTPTAIASPK--ATYVQDSPAETKTYNS 482

  Fly   467 VNIIDKYSRMIFPISFLAFNLGYWLFYI 494
            |:.:||.||:|||:.|..|||.||..|:
Mouse   483 VSKVDKISRIIFPVLFAIFNLVYWATYV 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	166/480 (35%)
		Neur_chan_LBD	47..256	CDD:280998	78/212 (37%)
		Neur_chan_memb	263..490	CDD:280999	77/238 (32%)
Gabra3	NP_001344745.1	Neur_chan_LBD	100..509	CDD:332142	163/466 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810