Protein Alignment Lcch3 and Gabrg1

DIOPT Version :10

• Sequence 1: NP_996469.1
• Gene: Lcch3 / 32554
• FlyBaseID: FBgn0010240
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_542153.1
• Gene: Gabrg1 / 140674
• RGDID: 621732
• Length: 465
• Species: Rattus norvegicus
• Alignment Length: 505
• Identity: 175/505 - (34%)
• Similarity: 250/505 - (49%)
• Gaps: 87/505 - (17%)

  Fly    13 LFFFLLGAQLQLIRCIRKD--------------VLAGRLE--NVTQTISNILQGYDIRLRPNFGG 61
            |.|.||  .|.|..||.|.              |||.::.  ::||.::::|||||.:|||:.|.
  Rat    23 LIFLLL--TLHLGNCIDKADDEDDEDLTMNKTWVLAPKIHEGDITQILNSLLQGYDNKLRPDIGV 85

  Fly    62 EPLHVGMDLTIASFDAISEVNMDYTITMYLNQYWRDERLAFNIFGQYFDDENDDGISDVLTLSGD 126
            .|..:..|:.:.|...:..:||:|||.:...|.|.|.||.||            ....||.|:.:
  Rat    86 RPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWFDSRLKFN------------STMKVLMLNSN 138

  Fly   127 FAEKIWVPDTFFANDKNSFLHDVTERNKLVRLGGDGAVTYGMRFTTTLACMMDLHYYPLDSQNCT 191
            ...|||:|||||.|.:.|..|.:|..|:|:|:..||.|.|.:|.|....|.:.||.:|:|..:|.
  Rat   139 MVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWSDGRVLYTLRLTINAECYLQLHNFPMDEHSCP 203

  Fly   192 VEIESYGYTVSDVVMYWKPTPVRGVEDAE---LPQFTIIGYETNDRKERLATGVYQRLSLSFKLQ 253
            :|..||||..:::...||...|. |.|.:   |.||..:|...:.......:|.|..:::.|.|.
  Rat   204 LEFSSYGYPKNEIEYKWKKPSVE-VADPKYWRLYQFAFVGLRNSTEISHTISGDYIIMTIFFDLS 267

  Fly   254 RNIGYFVFQTYLPSILIVMLSWVSFWINHEATSARVALGITTVLTMTTISTGVRSSLPRISYVKA 318
            |.:|||..|||:|.||.|:|||||||||.:|..||.:|||||||||||:||..|.|||::|||.|
  Rat   268 RRMGYFTIQTYIPCILTVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTA 332

  Fly   319 IDIYLVMCFVFVFAALLEYAAVNYTYWGKRAK----KKIKKVKECCPGKIGKSERSETCSTTEDI 379
            :|:::.:||:||||||:||..::|.....:.|    :|:|......||....|          .:
  Rat   333 MDLFVSVCFIFVFAALMEYGTLHYFTSNNKGKTTRDRKLKSKTSVSPGLHAGS----------TL 387

  Fly   380 IELQDVRMSPIPSLRRGTYNATLDSIGTETMNLGKFPPSFRITRNYGTGHSQLRRRAQRGISTRP 444
            |.:.::      |:.:|.     |..|.:.:........|....:..||            |.|.
  Rat   388 IPMNNI------SMPQGE-----DDYGYQCLEGKDCATFFCCFEDCRTG------------SWRE 429

  Fly   445 RMLHALKRGASAIKATIPKIKDVNIIDKYSRMIFPISFLAFNLGYWLFYI 494
            ..:|          ..|.|      ||.|||:.||.:|..|||.||:.|:
  Rat   430 GRIH----------IRIAK------IDSYSRIFFPTAFALFNLVYWVGYL 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	173/500 (35%)
Gabrg1	NP_542153.1	LIC	66..462	CDD:455710	161/457 (35%)
		LGIC_ECD_GABAAR_G	88..269	CDD:349801	62/193 (32%)
		Cys-loop	188..202	CDD:349801	5/13 (38%)