DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lcch3 and AgaP_AGAP001913

DIOPT Version :9

Sequence 1:	NP_996469.1	Gene:	Lcch3 / 32554	FlyBaseID:	FBgn0010240	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	XP_321152.5	Gene:	AgaP_AGAP001913 / 1281213	VectorBaseID:	AGAP001913	Length:	443	Species:	Anopheles gambiae

Alignment Length:	509	Identity:	146/509 - (28%)
Similarity:	233/509 - (45%)	Gaps:	112/509 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GAQLQLIRCIRKDVLAGRLENVTQTISNIL----QGYDIRLRPNFGGEPLHVGMDLTIASFDAIS 79
            |..|.:.:|:|:  :.|..: .:.|.::||    :.||....|...|:|..|...:|:...|:|.
Mosquito     9 GLLLMVAQCVRE--INGEYQ-TSLTFNDILPEDPKLYDKMRPPKKEGQPTIVFFHVTVMGLDSID 70

  Fly    80 EVNMDYTITMYLNQYWRDERLAF--NIFGQYFDDENDDGISDVLTLSGDFAEKIWVPDTFFANDK 142
            |.:|.|...::..|.|:|.||..  |:..:|            ..|..|:.:.:|.||:||.|.|
Mosquito    71 ENSMTYAADIFFAQTWKDHRLRLPENMTSEY------------RLLEVDWLKNMWRPDSFFKNAK 123

  Fly   143 NSFLHDVTERNKLVRLGGDGAVTYGMRFTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMY 207
            :.....:|..|..:.|..|..:.|.::.|..|:|.|:...||.|:|.|.:::||..:|..|:|..
Mosquito   124 SVTFQTMTIPNHYMWLYKDKTILYMVKLTLKLSCAMNFLIYPHDTQECKLQMESLSHTTDDLVFQ 188

  Fly   208 WK-PTPVRGVEDA--ELPQFTIIGYETNDRKERLATGVYQRLSLSFKLQRNIGYFVFQTYLPSIL 269
            |. ..|:  |.||  ||||..::...|.|..:..:||.:..|.:.|.|:|.:||::|.||:|:.|
Mosquito   189 WDLEVPL--VVDAHIELPQLALVKNYTADCTQVYSTGNFTCLEVVFVLKRRLGYYLFHTYIPTCL 251

  Fly   270 IVMLSWVSFWINHEATSARVALGITTVLTMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAAL 334
            ||::|||||||..||..|||.||:|::||::|.....::|||.:||:||:|.::.:|.||||.||
Mosquito   252 IVIMSWVSFWIKPEAAPARVTLGVTSLLTLSTQHAKSQASLPPVSYLKAVDAFMSVCTVFVFMAL 316

  Fly   335 LEYAAVN----------------------YTYWGKRAKKKIKKVKECCPGKIGKSERSETCSTTE 377
            :||..||                      :.:..|..|:..|..:......|...:|.|:
Mosquito   317 MEYCLVNIVLGDSDPPSPPKPHPPKMDKFFDFTAKNGKRNSKSHEHPHDIPITTFQRQES----- 376

  Fly   378 DIIELQDVRMSPIPSLRRGTYNATLDSIGTETMNLGKFPPSFRITRNYGTGHSQLRRRAQRGIST 442
                  .:.:||:|.::                   ..||.                      ..
Mosquito   377 ------TLLLSPVPHIQ-------------------TIPPP----------------------PC 394

  Fly   443 RPRMLHALKRGASAIKATIP---KIKDVNIIDKYSRMIFPISFLAFNLGYWLFY 493
            :|         ||||....|   ::|....||::||:.||..|...|:.||:.:
Mosquito   395 KP---------ASAIPKLTPAQMRLKRAINIDRFSRVFFPFLFTLLNVTYWIMF 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	146/507 (29%)
		Neur_chan_LBD	47..256	CDD:280998	66/217 (30%)
		Neur_chan_memb	263..490	CDD:280999	69/251 (27%)
AgaP_AGAP001913	XP_321152.5	LIC	10..437	CDD:273305	144/504 (29%)
		Neur_chan_LBD	42..237	CDD:280998	63/208 (30%)
		Neur_chan_memb	245..436	CDD:280999	69/251 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810