DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lcch3 and AgaP_AGAP005599

DIOPT Version :9

Sequence 1:	NP_996469.1	Gene:	Lcch3 / 32554	FlyBaseID:	FBgn0010240	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	XP_315611.3	Gene:	AgaP_AGAP005599 / 1276287	VectorBaseID:	AGAP005599	Length:	453	Species:	Anopheles gambiae

Alignment Length:	454	Identity:	115/454 - (25%)
Similarity:	194/454 - (42%)	Gaps:	64/454 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 DIRL--RPNFGGEPLHVGMDLTIASFDAISEVNMDYTITMYLNQYWRDERLAFNIFGQYFDDEND 114
            |:|:  ||...| .|.|.:.:.:.|..:..|.::.|.:...|.|.|.|.||.:....||   |..
Mosquito    48 DMRVPGRPQNRG-TLTVNVSVLLLSLASPDESSLKYEVEFLLQQQWFDPRLRYANQSQY---EYL 108

  Fly   115 DGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKLVRLGGDGAVTYGMRFTTTLACMMD 179
            :.|        ...|.||:|||:|.. ...|...:...:..:|:..:|.:.|.||....|:|...
Mosquito   109 NAI--------HHHEDIWLPDTYFIM-HGDFKDPIIPMHFALRIYRNGTINYLMRRHLILSCQGR 164

  Fly   180 LHYYPLDSQNCTVEIESYGYTVSDVVMYWKPTPVRGVEDA--ELPQFTII-GYETNDRKERLA-- 239
            |:.:|.|...|:..:||..|..|.:...||     ..||.  :.|..|.: .|..  :.:.:|
Mosquito   165 LNIFPFDDPLCSFALESISYEQSAITYVWK-----NDEDTLRKSPSLTTLNAYLI--QNQTIACP 222

  Fly   240 -----TGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHEATSARVALGITTVLTM 299
                 .|.|..|.:.....|:..::....::|.|::|..|:::||:...|..||..:|:||:|..
Mosquito   223 IKASWRGNYSCLKVDLIFTRDRAFYFTTVFIPGIILVTSSFITFWLEWNAVPARSMIGVTTMLNF 287

  Fly   300 TTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVNYTYWGKRAKKKIKKVKECCPGKI 364
            .|.|.|.||:||.:|.:.|::::..:|..|::|:|||:..|||.  |:  |:.:..| ...||:.
Mosquito   288 FTTSNGFRSTLPVVSNLTAMNVWDGVCMCFIYASLLEFVCVNYV--GR--KRPLHNV-VYRPGEN 347

  Fly   365 GKSERSETCSTTEDIIELQDVRMSPIPSLRRGTYNATLDSIGTETMNLGKFPPSFRITRNYGTGH 429
            ..::|.....:...||     ..||:...:|       :|.|         |.......:...|.
Mosquito   348 PVTQRLPAVLSRIGII-----LASPLGVKKR-------ESGG---------PNEIVACTSCAGGT 391

  Fly   430 SQLRRRAQRGISTRPRMLHALKRGASAIKATIPKIKDVNIIDKYSRMIFPISFLAFNLGYWLFY 493
            |.....|..|.:|....:...|      |.....|:....||..:|:.||.::..|.:.:::.|
Mosquito   392 SPCTHSANNGCATETCFVQVRK------KEPPHPIRVAKTIDVIARITFPSAYAVFLIFFFIHY 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	114/452 (25%)
		Neur_chan_LBD	47..256	CDD:280998	55/215 (26%)
		Neur_chan_memb	263..490	CDD:280999	59/226 (26%)
AgaP_AGAP005599	XP_315611.3	Neur_chan_LBD	8..241	CDD:280998	54/212 (25%)
		LIC	9..449	CDD:273305	114/452 (25%)
		Neur_chan_memb	253..446	CDD:280999	59/224 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910