DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lcch3 and AgaP_AGAP000038

DIOPT Version :9

Sequence 1:	NP_996469.1	Gene:	Lcch3 / 32554	FlyBaseID:	FBgn0010240	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	XP_311123.3	Gene:	AgaP_AGAP000038 / 1272239	VectorBaseID:	AGAP000038	Length:	471	Species:	Anopheles gambiae

Alignment Length:	473	Identity:	385/473 - (81%)
Similarity:	421/473 - (89%)	Gaps:	14/473 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 AGRLENVTQTISNILQGYDIRLRPNFGGEPLHVGMDLTIASFDAISEVNMDYTITMYLNQYWRDE 98
            ||||||||||||.||:||||||||||||||||||||||||||||||||||||||||||||||:||
Mosquito     3 AGRLENVTQTISRILEGYDIRLRPNFGGEPLHVGMDLTIASFDAISEVNMDYTITMYLNQYWKDE 67

  Fly    99 RLAFNIFGQYFDDE---------NDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNK 154
            |||||.|..:.|::         .|||.:||:|||||||||||||||||||||||||||||||||
Mosquito    68 RLAFNAFALWGDNQKDQTGEIMIEDDGANDVITLSGDFAEKIWVPDTFFANDKNSFLHDVTERNK 132

  Fly   155 LVRLGGDGAVTYGMRFTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYWKPTPVRGVEDA 219
            ||||.|||||||||||||||||||||||||||||||||||||||||||||||||:.||:||||:|
Mosquito   133 LVRLAGDGAVTYGMRFTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYWRSTPIRGVEEA 197

  Fly   220 ELPQFTIIGYETNDRKERLATGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHEA 284
            |||||||||||||||||:||||:||||||||||||||||||||||||||||||||||||||||||
Mosquito   198 ELPQFTIIGYETNDRKEKLATGIYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHEA 262

  Fly   285 TSARVALGITTVLTMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVNYTYWGKRA 349
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||
Mosquito   263 TSARVALGITTVLTMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVNYTYWGARA 327

  Fly   350 KKKIKKVKECCPGKIGKSERSETCSTTEDIIELQDVRMSPIPSLRRGTYNATLDSIGTETMNLGK 414
            |||.||.||......||:|::.||| .:|||||||:|||||.|||...|:.|:.:  |::::..|
Mosquito   328 KKKSKKNKEAERKVFGKTEKTSTCS-ADDIIELQDIRMSPIASLRNRHYSNTITT--TDSVDSAK 389

  Fly   415 FPPSFRITRNYGTGH-SQLRRRAQRGISTRPRMLHALKRGASAIKATIPKIKDVNIIDKYSRMIF 478
            |||||||.|:||:.: |.||.|:.|| ..||:||||:|||||.|||:||||||||:||||||:||
Mosquito   390 FPPSFRIARSYGSSNRSGLRYRSSRG-QGRPKMLHAIKRGASVIKASIPKIKDVNVIDKYSRVIF 453

  Fly   479 PISFLAFNLGYWLFYILE 496
            |:||.|||.|||:||:||
Mosquito   454 PVSFAAFNAGYWIFYVLE 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	381/468 (81%)
		Neur_chan_LBD	47..256	CDD:280998	188/217 (87%)
		Neur_chan_memb	263..490	CDD:280999	171/227 (75%)
AgaP_AGAP000038	XP_311123.3	LIC	2..468	CDD:273305	381/468 (81%)
		Neur_chan_LBD	10..234	CDD:280998	193/223 (87%)
		Neur_chan_memb	241..465	CDD:280999	171/227 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	399	1.000	Domainoid score	I2155
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H633
Inparanoid	1	1.050	767	1.000	Inparanoid score	I1556
OMA	1	1.010	-	-		QHG47165
OrthoDB	1	1.010	-	-		D226476at33208
OrthoFinder	1	1.000	-	-		FOG0001081
OrthoInspector	1	1.000	-	-		otm50019
Panther	1	1.100	-	-	LDO	PTHR18945
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X650
TreeFam	1	0.960	-	-
	13	12.940