DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lcch3 and Glra3

DIOPT Version :9

Sequence 1:	NP_996469.1	Gene:	Lcch3 / 32554	FlyBaseID:	FBgn0010240	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_536686.3	Gene:	Glra3 / 110304	MGIID:	95749	Length:	464	Species:	Mus musculus

Alignment Length:	504	Identity:	186/504 - (36%)
Similarity:	272/504 - (53%)	Gaps:	87/504 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 GLFFFLLGAQLQLIRCIRKDVLAGRLENVTQTISNIL-------QGYDIRLRPNFGGEPLHVGMD 69
            |.:|:.....|.|:  ..|:..:.|..:...:.|:.|       .|||.|:||||.|.|::|..:
Mouse    13 GFYFWEAALLLSLV--ATKETNSARSRSAPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCN 75

  Fly    70 LTIASFDAISEVNMDYTITMYLNQYWRDERLAFNIFGQYFDDENDDGISDVLTLSGDFAEKIWVP 134
            :.|.||.:|:|..|||.:.::|.|.|.|.|||::   :|.||.        |.|.....:.||.|
Mouse    76 IFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYS---EYPDDS--------LDLDPSMLDSIWKP 129

  Fly   135 DTFFANDKNSFLHDVTERNKLVRLGGDGAVTYGMRFTTTLACMMDLHYYPLDSQNCTVEIESYGY 199
            |.||||:|.:..|:||..|||:|:..:|.|.|.:|.|.||:|.|||..:|:|.|.|.:::||:||
Mouse   130 DLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGY 194

  Fly   200 TVSDVVMYWK-PTPVRGVEDAELPQFTIIGYETNDRK---ERLATGVYQRLSLSFKLQRNIGYFV 260
            |::|::..|: ..||:..|...||||.:  .|..|.:   :...||.:..:.:.|.|:|.:||::
Mouse   195 TMNDLIFEWQDEAPVQVAEGLTLPQFLL--KEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYL 257

  Fly   261 FQTYLPSILIVMLSWVSFWINHEATSARVALGITTVLTMTTISTGVRSSLPRISYVKAIDIYLVM 325
            .|.|:||:|||:|||||||||.:|..|||||||||||||||.|:|.|:|||::||||||||::.:
Mouse   258 IQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAV 322

  Fly   326 CFVFVFAALLEYAAVNYTYWGKRAKKKIKKVKECCPGKIG--KSERSETCSTTEDIIELQDVRMS 388
            |.:|||:|||||||||:.   .|..|::.:.:.....|..  ..|:....|.|:|     :||.|
Mouse   323 CLLFVFSALLEYAAVNFV---SRQHKELLRFRRKRKNKTEAFALEKFYRFSDTDD-----EVRES 379

  Fly   389 PIPSLRRGTYNATLDSIGTETMNLGKFPPSFRITRNYGTGHSQLRRRAQRGISTRPRMLHALKRG 453
                  |.::.|                        ||.|..   .:|:.|:         :.:|
Mouse   380 ------RFSFTA------------------------YGMGPC---LQAKDGV---------VPKG 402

  Fly   454 ASAIKATIPKIKD---------VNIIDKYSRMIFPISFLAFNLGYWLFY 493
            .:.....:||..|         ...||..||..||::||.||:.||:.|
Mouse   403 PNHAVQVMPKSPDEMRKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIY 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	184/499 (37%)
		Neur_chan_LBD	47..256	CDD:280998	84/219 (38%)
		Neur_chan_memb	263..490	CDD:280999	89/237 (38%)
Glra3	NP_536686.3	LIC	12..451	CDD:273305	185/502 (37%)
Glra3	NP_536686.3	Strychnine-binding. /evidence=ECO:0000250\|UniProtKB:O75311	235..240		2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810