Protein Alignment Lcch3 and gabra5

DIOPT Version :10

• Sequence 1: NP_996469.1
• Gene: Lcch3 / 32554
• FlyBaseID: FBgn0010240
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: XP_004911866.1
• Gene: gabra5 / 100494208
• XenbaseID: XB-GENE-980292
• Length: 475
• Species: Xenopus tropicalis
• Alignment Length: 519
• Identity: 170/519 - (32%)
• Similarity: 247/519 - (47%)
• Gaps: 95/519 - (18%)

  Fly     1 MTCFTRVGVS---CGLFFFL---LGAQLQLIRCIRKDVLAGRLENV---TQTISNILQGYDIRLR 56
            |.|..:..||   ..|||.|   |.....:.:.....|.....:|:   |:.:..:|.|||.|||
 Frog     5 MNCKVKSSVSQIEAILFFCLFLALATNFSMSQTTAAPVKEDTNDNITIFTRILDGLLDGYDNRLR 69

  Fly    57 PNFGGEPLHVGMDLTIASFDAISEVNMDYTITMYLNQYWRDERLAFNIFGQYFDDENDDGISDVL 121
            |..|.....|..|:.:.||..:|:..|:|||.::..|.|:||||.|            .|....|
 Frog    70 PGLGERITQVKTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLCF------------QGPMPRL 122

  Fly   122 TLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKLVRLGGDGAVTYGMRFTTTLACMMDLHYYPLD 186
            .|:...|.|||.|||||.|.|.|..|::|..|||:||..||.:.|.||.|.:..|.|.|..:|:|
 Frog   123 PLNNLLASKIWTPDTFFHNGKKSIAHNITTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDFPMD 187

  Fly   187 SQNCTVEIESYGYTVSDVVMYWKPTPVRGVEDAE----LPQFTIIGYETNDRKERLATGVYQRLS 247
            :..|.::..||.|..|::...|.....:.|..||    |.|:.:||..........:||.|..::
 Frog   188 AHACPLKFGSYAYPNSELRYEWTNITDKSVVVAEDGSRLNQYHLIGQTVGTENISTSTGEYTVMT 252

  Fly   248 LSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHEATSARVALGITTVLTMTTISTGVRSSLPR 312
            ..|.|:|.|||||.|||||.|:.|:||.||||:|.|:..||...|:||||||||:|...|:|||:
 Frog   253 AHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPK 317

  Fly   313 ISYVKAIDIYLVMCFVFVFAALLEYAAVNY---TYWGKRAKKKIKKVKECCPGKIGKSERSETCS 374
            ::|..|:|.::.:|:.|||:||:|:|.|||   ..|....||.::      ..||.|.|:
 Frog   318 VAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRSWAWDGKKALE------AAKIKKKEQ----- 371

  Fly   375 TTEDIIELQDVRMSPIPSLRRGTYNATLDSIGTETMN--LGKFPPSFRITRNYGTGHSQLRRRAQ 437
                                        :|:|.:.:|  .|:.|.:..::::..:
 Frog   372 ----------------------------ESLGRKPINSYSGRIPYTPNMSKDLTS---------- 398

  Fly   438 RGISTRPRMLHALKRGASAIKATIPKIKD-------VNIIDKYSRMIFPISFLAFNLGYWLFYI 494
             .:......:|        :|.|..|..:       |:.|||.||::||:.|..|||.||..|:
 Frog   399 -SVIANAASIH--------MKTTEEKCAESKKTYNSVSKIDKMSRIVFPVMFGTFNLVYWATYL 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	163/499 (33%)
gabra5	XP_004911866.1	LIC	25..452	CDD:455710	161/496 (32%)
		LGIC_ECD_GABAAR_A5	62..260	CDD:349839	75/209 (36%)
		Cys-loop	177..191	CDD:349839	5/13 (38%)