Protein Alignment CG8916 and GLRA3

DIOPT Version :9

• Sequence 1: NP_573090.3
• Gene: CG8916 / 32553
• FlyBaseID: FBgn0030707
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_006520.2
• Gene: GLRA3 / 8001
• HGNCID: 4328
• Length: 464
• Species: Homo sapiens
• Alignment Length: 520
• Identity: 167/520 - (32%)
• Similarity: 255/520 - (49%)
• Gaps: 98/520 - (18%)

  Fly    95 VRRKAAADMLSRNISM----ILENLLKR---YEQSQLPTHGQGVPTVVQTNILIRSMGPVSELDM 152
            |..|......||:..|    .|:.|:.|   |: :::..:.:|.|..|..||.|.|.|.::|..|
Human    26 VATKETDSARSRSAPMSPSDFLDKLMGRTSGYD-ARIRPNFKGPPVNVTCNIFINSFGSIAETTM 89

  Fly   153 DYSMDCYFRQYWRDKRLSF-KGPIKSLSLSIKMLDKIWRPDTYFYNGKHSQIHMITVPNKLLRLD 216
            ||.::.:.||.|.|.||:: :.|..||.|...|||.||:||.:|.|.|.:..|.:|..|||||:.
Human    90 DYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIF 154

  Fly   217 QNGGILYSMRLTIKATCPMELQNFPMDRQSCPLVIGSYGYINQQLIYEWKNQDDA-VSFVPGMTL 280
            :||.:|||:|||:..:|||:|:|||||.|:|.:.:.|:||....||:||  ||:| |....|:||
Human   155 KNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEW--QDEAPVQVAEGLTL 217

  Fly   281 NQFDLISMMHRNFTTVR-REGDFSVLHVAFNLKRHTGYFLIQVYVPCILIVVLSWVSFWIHREAT 344
            .||.|.......:.|.. ..|.|:.:.|.|:|:|..||:|||:|:|.:|||:||||||||:.:|.
Human   218 PQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAA 282

  Fly   345 SDRVSLCVTSVLTLSTISLDSRTDLPKVKYATALDWFLLMSFLYCIATLLEFAGVHYFTKLGSGE 409
            ..||:|.:|:|||::|.|..||..||||.|..|:|.::.:..|:..:.|||:|.|::.::
Human   283 PARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSR----- 342

  Fly   410 SPQLEDQWEDICIANSLSDHAGEVDGDGEADADPFADEDSSNGSENDDNEAGASESVESKSGVCV 474
                  |.:::........:..|.          ||.|.....|:.||      |..||:...
Human   343 ------QHKELLRFRRKRKNKTEA----------FALEKFYRFSDMDD------EVRESRFSF-- 383

  Fly   475 CNKNDALGLEYEVSLQNSLAGAGFLKRNAIFCPTYNDPSYILPNTMERTTQTEPPAVSRLHQMWM 539
                .|.|:...:..::.:...|         |  |.|..::|
Human   384 ----TAYGMGPCLQAKDGMTPKG---------P--NHPVQVMP---------------------- 411

  Fly   540 CLKSDNSFRKQRERNAAAQKSEQGGANCYVNSVSLIDRVARIAFPMSFAFLNLLYWWAYGMYKKE 604
              ||.:..||                 .:::....||.::|..||::|...|:.||..|.:.:.|
Human   412 --KSPDEMRK-----------------VFIDRAKKIDTISRACFPLAFLIFNIFYWVIYKILRHE 457

  Fly   605  604
            Human   458  457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8916	NP_573090.3	LIC	92..598	CDD:273305	165/512 (32%)
		Neur_chan_LBD	111..315	CDD:280998	86/209 (41%)
		Neur_chan_memb	322..>403	CDD:280999	38/80 (48%)
GLRA3	NP_006520.2	LIC	12..451	CDD:273305	165/512 (32%)
		Strychnine-binding. /evidence=ECO:0000269|PubMed:26416729	235..240		1/4 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810